{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T09:27:06Z","timestamp":1779010026488,"version":"3.51.4"},"reference-count":19,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Trends in serotype incidence and susceptibility (1997 to 2008) of Spanish\n            <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n            pleural isolates (\n            <jats:italic>n<\/jats:italic>\n            = 831) were explored. Penicillin (oral) nonsusceptibility rates and the incidence of 7-valent pneumococcal conjugate vaccine (PCV-7) serotypes showed decreasing trends (\n            <jats:italic>R<\/jats:italic>\n            <jats:sup>2<\/jats:sup>\n            \u2265 0.600;\n            <jats:italic>P<\/jats:italic>\n            \u2264 0.002). The incidence of serotypes 1 and 19A showed increasing trends (\n            <jats:italic>R<\/jats:italic>\n            <jats:sup>2<\/jats:sup>\n            \u2265 0.759;\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001), with no trends for serotype 3. Serotypes 19A, 1, and 3 represented 85% of pediatric isolates in 2008. In serotype 19A, the penicillin nonsusceptibility rate was 82.4% in 2008, associated with amoxicillin and cefotaxime nonsusceptibility in 21.4% of isolates. Inclusion of these serotypes in new vaccines offers the broadest coverage.\n          <\/jats:p>","DOI":"10.1128\/aac.00217-10","type":"journal-article","created":{"date-parts":[[2010,10,5]],"date-time":"2010-10-05T04:24:45Z","timestamp":1286252685000},"page":"5387-5390","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Serotype Distribution and Susceptibility of\n            <i>Streptococcus pneumoniae<\/i>\n            Isolates from Pleural Fluid in Spain from 1997 to 2008"],"prefix":"10.1128","volume":"54","author":[{"given":"A.","family":"Fenoll","sequence":"first","affiliation":[{"name":"Spanish Reference Pneumococcal Laboratory, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Microbiology Department, School of Medicine, Universidad Complutense, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. D.","family":"Vicioso","sequence":"additional","affiliation":[{"name":"Spanish Reference Pneumococcal Laboratory, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Gimenez","sequence":"additional","affiliation":[{"name":"Microbiology Department, School of Medicine, Universidad Complutense, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Robledo","sequence":"additional","affiliation":[{"name":"Spanish Reference Pneumococcal Laboratory, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J.","family":"Granizo","sequence":"additional","affiliation":[{"name":"Grana Datos, Pozuelo de Alarco\u0301n, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Mendez","sequence":"additional","affiliation":[{"name":"Medical Department, Pfizer S. A., Alcobendas, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp210"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01200-09"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000202137.37642.ab"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2006.1502_1.x"},{"key":"e_1_3_2_6_2","unstructured":"Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically seventh edition. 2006"},{"key":"e_1_3_2_7_2","unstructured":"Performance standards for antimicrobial susceptibility testing: nineteenth informational supplement M100-S19. 2009"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.016105"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn413"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00712-08"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp376"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.3.764-766.1997"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/13.1.56"},{"key":"e_1_3_2_14_2","unstructured":"Enfermedad invasora por Streptococcus pneumoniae. 2006"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(05)70083-9"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0184"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/524660"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1409.071094"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.16.1784"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022823"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00217-10","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00217-10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:21:42Z","timestamp":1645474902000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00217-10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["10.1128\/AAC.00217-10"],"URL":"https:\/\/doi.org\/10.1128\/aac.00217-10","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12]]},"assertion":[{"value":"2010-02-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-09-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}