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The second isolate developed resistance to ciprofloxacin and the third isolate to piperacillin-tazobactam (PIP-TZ) following sequential therapy with each agent. The first isolate was resistant to PIP-TZ only at high inocula, the second isolate acquired increased transcription of the\n            <jats:italic>acrA<\/jats:italic>\n            gene, and the third isolate became resistant to PIP-TZ due to loss of \u03b2-lactamase inhibition by TZ. We question if and how PIP-TZ susceptibility should be reported for ESBL-producing\n            <jats:italic>Enterobacteriaceae<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.00218-06","type":"journal-article","created":{"date-parts":[[2006,8,28]],"date-time":"2006-08-28T18:10:56Z","timestamp":1156788656000},"page":"3179-3182","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":51,"title":["Endocarditis Caused by Extended-Spectrum-\u03b2-Lactamase-Producing\n            <i>Klebsiella pneumoniae<\/i>\n            : Emergence of Resistance to Ciprofloxacin and Piperacillin-Tazobactam during Treatment despite Initial Susceptibility"],"prefix":"10.1128","volume":"50","author":[{"given":"Oren","family":"Zimhony","sequence":"first","affiliation":[{"name":"Infectious Diseases Division"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inna","family":"Chmelnitsky","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Molecular Epidemiology Laboratory, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Bardenstein","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sorel","family":"Goland","sequence":"additional","affiliation":[{"name":"Cardiology Division, Kaplan Medical Center Rehovot, Hebrew University and Hadassah, Jerusalem"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orly","family":"Hammer Muntz","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Molecular Epidemiology Laboratory, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiri","family":"Navon Venezia","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Molecular Epidemiology Laboratory, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yehuda","family":"Carmeli","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Molecular Epidemiology Laboratory, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/516330"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg114"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.2.509"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(85)80989-3"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/380645"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/40.4.533"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.4.1178-1182.2006"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.5.1520-1525.2004"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.1.190"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.10.3222-3232.2003"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.11.2580"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.10.3703-3711.2002"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.2.342"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-94-1-55"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.12.3984-3986.2002"},{"key":"e_1_3_1_17_2","unstructured":"NCCLS. 2002. 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