{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T09:52:22Z","timestamp":1793267542811,"version":"4.5.0"},"reference-count":33,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Foreign travel has been suggested to be a risk factor for the acquisition of extended-spectrum beta-lactamase (ESBL)-producing\n                    <jats:italic>Enterobacteriaceae<\/jats:italic>\n                    . To our knowledge, this has not previously been demonstrated in a prospective study. Healthy volunteers traveling outside Northern Europe were enrolled. Rectal swabs and data on potential travel-associated risk factors were collected before and after traveling. A total of 105 volunteers were enrolled. Four of them did not complete the study, and one participant carried ESBL-producing\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    before travel. Twenty-four of 100 participants with negative pretravel samples were colonized with ESBL-producing\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    after the trip. All strains produced CTX-M enzymes, mostly CTX-M-15, and some coproduced TEM or SHV enzymes. Coresistance to several antibiotic subclasses was common. Travel to India was associated with the highest risk for the acquisition of ESBLs (88%;\n                    <jats:italic>n<\/jats:italic>\n                    = 7). Gastroenteritis during the trip was an additional risk factor (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.003). Five of 21 volunteers who completed the follow-up after 6 months had persistent colonization with ESBLs. This is the first prospective study demonstrating that international travel is a major risk factor for colonization with ESBL-producing\n                    <jats:italic>Enterobacteriaceae<\/jats:italic>\n                    . Considering the high acquisition rate of 24%, it is obvious that global efforts are needed to meet the emergence and spread of CTX-M enzymes and other antimicrobial resistances.\n                  <\/jats:p>","DOI":"10.1128\/aac.00220-10","type":"journal-article","created":{"date-parts":[[2010,6,15]],"date-time":"2010-06-15T00:11:20Z","timestamp":1276560680000},"page":"3564-3568","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":327,"title":["Foreign Travel Is a Major Risk Factor for Colonization with\n                    <i>Escherichia coli<\/i>\n                    Producing CTX-M-Type Extended-Spectrum \u03b2-Lactamases: a Prospective Study with Swedish Volunteers"],"prefix":"10.1128","volume":"54","author":[{"given":"Thomas","family":"Ta\u0308ngde\u0301n","sequence":"first","affiliation":[{"name":"Sections of Infectious Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto","family":"Cars","sequence":"additional","affiliation":[{"name":"Sections of Infectious Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u030asa","family":"Melhus","sequence":"additional","affiliation":[{"name":"Clinical Bacteriology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Lo\u0308wdin","sequence":"additional","affiliation":[{"name":"Sections of Infectious Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/533475"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2008.0020"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01848.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01850.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-003-1084-2"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1438"},{"key":"e_1_3_2_8_2","unstructured":"Annual report 2005. 2006"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/590941"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2005.10.001"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01855.x"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2005.04.004"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm144"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/10.4.867"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/519865"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2008.09.034"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2008.02089.x"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2008.00922.x"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(02)00466-2"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2003.07.004"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2009.02.003"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00061-09"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.12.5715-5721.2004"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn293"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.3.1089-1094.2004"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01884.x"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01867.x"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.2807\/ese.14.32.19300-en"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1086\/313770"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365540903493715"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.10.4769-4775.2004"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01869.x"},{"key":"e_1_3_2_33_2","doi-asserted-by":"crossref","first-page":"S94","DOI":"10.1086\/320182","volume":"32","year":"2001","unstructured":"Winokur, P. 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