{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T11:19:15Z","timestamp":1774610355295,"version":"3.50.1"},"reference-count":92,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["310030-162583"],"award-info":[{"award-number":["310030-162583"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>Despite appropriate antibiotic therapy, pneumococcal meningitis (PM) is associated with a case fatality rate of up to 30% in high-income countries. Survivors often suffer from severe lifelong disabilities.<\/jats:p>","DOI":"10.1128\/aac.00220-19","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T17:39:30Z","timestamp":1557164370000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":23,"title":["Combining Ceftriaxone with Doxycycline and Daptomycin Reduces Mortality, Neuroinflammation, Brain Damage, and Hearing Loss in Infant Rat Pneumococcal Meningitis"],"prefix":"10.1128","volume":"63","author":[{"given":"Lukas","family":"Muri","sequence":"first","affiliation":[{"name":"Neuroinfection Laboratory, Institute for Infectious Diseases, University of Bern, Bern, Switzerland"},{"name":"Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Perny","sequence":"additional","affiliation":[{"name":"Neuroinfection Laboratory, Institute for Infectious Diseases, University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Zemp","sequence":"additional","affiliation":[{"name":"Neuroinfection Laboratory, Institute for Infectious Diseases, University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4151-5196","authenticated-orcid":false,"given":"Denis","family":"Grandgirard","sequence":"additional","affiliation":[{"name":"Neuroinfection Laboratory, Institute for Infectious Diseases, University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1106-6123","authenticated-orcid":false,"given":"Stephen L.","family":"Leib","sequence":"additional","affiliation":[{"name":"Neuroinfection Laboratory, Institute for Infectious Diseases, University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(02)00450-4"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f96297"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70048-7"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181ef25f7"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199305000-00008"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040845"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61187-8"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61808-X"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70023-5"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199903000-00006"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004010000326"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0304-8"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.10142"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000096218"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00008-11"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/425520"},{"key":"e_1_3_2_18_2","first-page":"341","volume-title":"Infections of the central nervous system","author":"Agyeman P","year":"2014","unstructured":"Agyeman P, Grandgirard D, Leib SL. 2014. Pathogenesis and pathophysiology of bacterial infections, p 341\u2013364. In Scheld MW, Marra CM, Whitley RJ (ed), Infections of the central nervous system. Lippincott Williams & Wilkins, Philadelphia, PA."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-0670fje"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/13550280802093927"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)01645-1"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1086\/317921"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)02024-5"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000079185.67878.72"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2017.04.012"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0554-16.2016"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2003.tb00012.x"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004405.pub5"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2016.01.007"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0395"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000227553.47378.9f"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e318123fb7c"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00674-12"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00073-14"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.9.1734"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1086\/315658"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00148-13"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10684"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-0989-0"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57522"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-9-50"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0372-y"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1272-8"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.03.039"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01000-06"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01014-06"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl007"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01741-10"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.10.3928-3933.2004"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.28.2.347"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000121571.78696.dc"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2002.1598"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1177\/08959374980120010501"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1086\/426545"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1991.tb01626.x"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.1.227"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01949-05"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440404"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.2.615-620.2000"},{"key":"e_1_3_2_60_2","unstructured":"The European Committee on Antimicrobial Susceptibility Testing. 2019. Breakpoint tables for interpretation of MICs and zone diameters version 9.0. http:\/\/www.eucast.org\/clinical_breakpoints\/."},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg091"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.170.12.5931-5934.1988"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/151.5.859"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsim.2005.01.001"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.1.95-110.2002"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1086\/313922"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.10108"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600375"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2674-08.2008"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2005.09.007"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(01)00101-1"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3499"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202286"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000129334.05181.b6"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02736854"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh546"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1159\/000109868"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2009.02.031"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00812-09"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-14-42"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-200309000-00014"},{"key":"e_1_3_2_82_2","first-page":"2544","article-title":"Doxycycline inhibition of interleukin-1 in the corneal epithelium","volume":"41","author":"Solomon A","year":"2000","unstructured":"Solomon A, Rosenblatt M, Li DQ, Liu Z, Monroy D, Ji Z, Lokeshwar BL, Pflugfelder SC. 2000. Doxycycline inhibition of interleukin-1 in the corneal epithelium. Invest Ophthalmol Vis Sci 41:2544\u20132557.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23397"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02429-15"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199606000-00006"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1086\/319271"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-018-0657-y"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.21256"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.9.1988"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.5.1104"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-003-0672-7"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2008.01930.x"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.12.4883-4890.1996"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00220-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00220-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:34:44Z","timestamp":1645479284000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00220-19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":92,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1128\/AAC.00220-19"],"URL":"https:\/\/doi.org\/10.1128\/aac.00220-19","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"2019-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00220-19"}}