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This study identified a novel A172T mutation and other known\n                      <jats:italic toggle=\"yes\">penA<\/jats:italic>\n                      mutations as critical contributors to CAZ resistance in a large Thai strain collection. Frequent gene duplication and amplification of\n                      <jats:italic toggle=\"yes\">penA<\/jats:italic>\n                      , likely driven by Palindromic GC-Rich Repeat Sequences, highlights the urgent need for rapid diagnostics and optimized treatment strategies to manage this life-threatening disease effectively.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.00220-25","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T13:46:22Z","timestamp":1753105582000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Genomic insights into ceftazidime resistance in\n                    <i>Burkholderia pseudomallei<\/i>\n                    : discovery of A172T mutation and palindromic GC-rich repeat sequences facilitating\n                    <i>penA<\/i>\n                    duplication and amplification"],"prefix":"10.1128","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3380-0448","authenticated-orcid":true,"given":"Apichai","family":"Tuanyok","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida","place":["Gainesville, USA"]},{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"Emerging Pathogens Institute, University of Florida","place":["Gainesville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9194-1062","authenticated-orcid":true,"given":"Chie","family":"Nakajima","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02e16g702","id-type":"ROR","asserted-by":"publisher"}],"name":"Hokkaido University International Institute for Zoonosis Control","place":["Sapporo, Japan"]},{"id":[{"id":"https:\/\/ror.org\/02e16g702","id-type":"ROR","asserted-by":"publisher"}],"name":"Hokkaido University Institute for Vaccine Research and Development","place":["Sapporo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiernan","family":"Noll","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida","place":["Gainesville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. 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