{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T10:20:46Z","timestamp":1789813246572,"version":"4.0.1"},"reference-count":28,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100005869","name":"University of Fribourg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005869","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            An extended-spectrum \u03b2-lactamase (ESBL)-producing and colistin-resistant\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Klebsiella pneumoniae<\/jats:named-content>\n            clinical isolate was recovered from a patient who was treated with cefotaxime. This isolate harbored a\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CTX-M-15<\/jats:sub>\n            ESBL gene that was associated with an IS\n            <jats:italic>Ecp1<\/jats:italic>\n            insertion sequence. Transposition of that tandem occurred within the chromosomal\n            <jats:italic>mgrB<\/jats:italic>\n            gene, leading to inactivation of the\n            <jats:italic>mgrB<\/jats:italic>\n            gene and consequently to acquired resistance to colistin. We showed here a coselection of colistin resistance as a result of a broad-spectrum cephalosporin selective pressure.\n          <\/jats:p>","DOI":"10.1128\/aac.00237-16","type":"journal-article","created":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T03:39:18Z","timestamp":1457408358000},"page":"3199-3201","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":35,"title":["Acquisition of Broad-Spectrum Cephalosporin Resistance Leading to Colistin Resistance in Klebsiella pneumoniae"],"prefix":"10.1128","volume":"60","author":[{"given":"Aur\u00e9lie","family":"Jayol","sequence":"first","affiliation":[{"name":"Medical and Molecular Microbiology, Emerging Antibiotic Resistance Unit, Department of Medicine, Faculty of Science, University of Fribourg, Fribourg, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Nordmann","sequence":"additional","affiliation":[{"name":"Medical and Molecular Microbiology, Emerging Antibiotic Resistance Unit, Department of Medicine, Faculty of Science, University of Fribourg, Fribourg, Switzerland"},{"name":"HFR - H\u00f4pital Cantonal, Fribourg, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Desroches","sequence":"additional","affiliation":[{"name":"Department of Virology, Bacteriology-Infect Control, Parasitology-Mycology, Assistance Publique-H\u00f4pitaux de Paris, University Hospital Henri Mondor, Cr\u00e9teil, France"},{"name":"IAME, UMR 1137, INSERM, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Winoc","family":"Decousser","sequence":"additional","affiliation":[{"name":"Department of Virology, Bacteriology-Infect Control, Parasitology-Mycology, Assistance Publique-H\u00f4pitaux de Paris, University Hospital Henri Mondor, Cr\u00e9teil, France"},{"name":"IAME, UMR 1137, INSERM, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Poirel","sequence":"additional","affiliation":[{"name":"Medical and Molecular Microbiology, Emerging Antibiotic Resistance Unit, Department of Medicine, Faculty of Science, University of Fribourg, Fribourg, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2015.1018989"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"643","DOI":"10.3389\/fmicb.2014.00643","article-title":"Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria","volume":"5","author":"Olaitan AO","year":"2014","unstructured":"Olaitan AO, Morand S, Rolain JM. 2014. 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Detection of mcr-1 encoding plasmid-mediated colistin-resistant Escherichia coli isolates from human bloodstream infection and imported chicken meat Denmark 2015. Euro Surveill 20:pii=21331. http:\/\/www.eurosurveillance.org\/ViewArticle.aspx?ArticleId=21331.","DOI":"10.2807\/1560-7917.ES.2015.20.49.30085"},{"key":"e_1_3_2_12_2","article-title":"Co-occurrence of extended spectrum \u03b2-lactamase and MCR-1 encoding genes on plasmids","author":"Haenni M","unstructured":"Haenni M, Poirel L, Kieffer N, Ch\u00e2tre P, Saras E, M\u00e9tayer V, Dumoulin R, Nordmann P, Madec JY. Co-occurrence of extended spectrum \u03b2-lactamase and MCR-1 encoding genes on plasmids. Lancet Infect Dis, in press.","journal-title":"Lancet Infect Dis"},{"key":"e_1_3_2_13_2","article-title":"Colistin-resistant Escherichia coli harbouring mcr-1 isolated from food animals in Hanoi, Vietnam","author":"Malhotra-Kumar S","unstructured":"Malhotra-Kumar S, Xavier BB, Das AJ, Lammens C, Hoang HT, Pham NT, Goossens H. Colistin-resistant Escherichia coli harbouring mcr-1 isolated from food animals in Hanoi, Vietnam. Lancet Infect Dis, in press.","journal-title":"Lancet Infect Dis"},{"key":"e_1_3_2_14_2","article-title":"Plasmid-mediated carbapenem and colistin resistance in a clinical isolate of Escherichia coli","author":"Poirel L","unstructured":"Poirel L, Kieffer N, Liassine N, Thanh D, Nordmann P. Plasmid-mediated carbapenem and colistin resistance in a clinical isolate of Escherichia coli. 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