{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T20:44:56Z","timestamp":1775594696902,"version":"3.50.1"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The activities of ceftobiprole and other \u03b2-lactams were examined with 30\n            <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n            isolates containing multiple\n            <jats:italic>pbp1a<\/jats:italic>\n            ,\n            <jats:italic>pbp2b<\/jats:italic>\n            , and\n            <jats:italic>pbp2x<\/jats:italic>\n            mutations. The highest ceftobiprole MIC was 1 \u03bcg\/ml, while the comparator MICs were 16 to 64 \u03bcg\/ml. Fifty percent inhibitory concentrations for penicillin-binding protein 2x were 0.5 \u03bcg\/ml (ceftobiprole) and 4 \u03bcg\/ml (ceftriaxone) in a penicillin- and ceftriaxone-resistant isolate.\n          <\/jats:p>","DOI":"10.1128\/aac.00238-06","type":"journal-article","created":{"date-parts":[[2006,6,26]],"date-time":"2006-06-26T18:26:28Z","timestamp":1151346388000},"page":"2530-2532","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":32,"title":["Activities of Ceftobiprole and Other \u03b2-Lactams against\n            <i>Streptococcus pneumoniae<\/i>\n            Clinical Isolates from the United States with Defined Substitutions in Penicillin-Binding Proteins PBP 1a, PBP 2b, and PBP 2x"],"prefix":"10.1128","volume":"50","author":[{"given":"Todd A.","family":"Davies","sequence":"first","affiliation":[{"name":"Johnson &amp; Johnson Pharmaceutical Research &amp; Development, LLC, Raritan, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenchi","family":"Shang","sequence":"additional","affiliation":[{"name":"Johnson &amp; Johnson Pharmaceutical Research &amp; Development, LLC, Raritan, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Bush","sequence":"additional","affiliation":[{"name":"Johnson &amp; Johnson Pharmaceutical Research &amp; Development, LLC, Raritan, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.5.1252"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.9.2267"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/313954"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M511506200"},{"key":"e_1_3_2_6_2","unstructured":"Clinical Laboratory Standards Institute. 2006. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard 7th ed. M7-A7. Clinical Laboratory Standards Institute Wayne Pa."},{"key":"e_1_3_2_7_2","unstructured":"Clinical Laboratory Standards Institute. 2006. Performance standards for antimicrobial susceptibility testing. Sixteenth informational supplement. M100-S16. 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F. 2003. Resistance issues and community-acquired respiratory infections. Clin. Cornerstone5(Suppl. 3):S4-S11.","journal-title":"Clin. 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