{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:42:09Z","timestamp":1790484129174,"version":"4.1.0"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["T32 MH-19105"],"award-info":[{"award-number":["T32 MH-19105"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Recent observational studies have suggested possible reductions in mortality in patients receiving cefazolin versus antistaphylococcal penicillins. We examined 90-day mortality in patients receiving cefazolin compared to nafcillin for methicillin-susceptible\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Staphylococcus aureu<\/jats:named-content>\n            s (MSSA) bloodstream infection (BSI). We identified persons with MSSA BSI admitted to San Francisco General Hospital from January 2008 to July 2013 through a hospital-wide infection surveillance system and confirmed 90-day mortality using U.S. national vital registries. We included persons receiving cefazolin or nafcillin as the predominant intravenous antimicrobial agent; all participants received inpatient Infectious Diseases service consultation. We estimated the association between receipt of cefazolin and 90-day risk of death by multivariate logistic regression, including a propensity score for receiving cefazolin as the second predictor. Of 230 MSSA BSI cases, 30 received nafcillin and 70 received cefazolin as the predominant antimicrobial; 10 died within 90 days, 5 from each group. Unadjusted analysis showed substantial but not statistically significant reduced odds of death in those receiving cefazolin (odds ratio, 0.38; 95% confidence interval [CI], 0.10 to 1.44). Multivariate analysis with propensity scores found a similar adjusted odds ratio (0.40; 95% CI, 0.09 to 1.74;\n            <jats:italic>P<\/jats:italic>\n            = 0.22). We found a large reduction in 90-day mortality in those receiving cefazolin compared to nafcillin for MSSA BSI, but this finding was not statistically significant. The magnitude of effect seen in this and other studies justifies further study.\n          <\/jats:p>","DOI":"10.1128\/aac.00243-16","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T16:26:28Z","timestamp":1464107188000},"page":"4684-4689","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":45,"title":["Cefazolin versus Nafcillin for Methicillin-Sensitive Staphylococcus aureus Bloodstream Infection in a California Tertiary Medical Center"],"prefix":"10.1128","volume":"60","author":[{"given":"S.","family":"Pollett","sequence":"first","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics, University of California San Francisco, San Francisco, California, USA"},{"name":"Marie Bashir Institute for Infectious Diseases &amp; Biosecurity, University of Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2282-6140","authenticated-orcid":false,"given":"S. M.","family":"Baxi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics, University of California San Francisco, San Francisco, California, USA"},{"name":"Department of Medicine, University of California San Francisco, San Francisco, California, USA"},{"name":"Epidemiology Division, School of Public Health, University of California Berkeley, Berkeley, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. W.","family":"Rutherford","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics, University of California San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. B.","family":"Doernberg","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Bacchetti","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics, University of California San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. F.","family":"Chambers","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics, University of California San Francisco, San Francisco, California, USA"},{"name":"Department of Medicine, University of California San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/598189"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268806007631"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12144"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.05022-11"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2006.01589.x"},{"key":"e_1_3_2_7_2","author":"Centers for Disease Control and Prevention","year":"2014","unstructured":"Centers for Disease Control and Prevention. 2014. Active Bacterial Core surveillance (ABCs) list of pathogens. Centers for Disease Control and Prevention, Atlanta, GA. http:\/\/www.cdc.gov\/abcs\/pathogens\/pathogen-links.html.","journal-title":"Active Bacterial Core surveillance (ABCs) list of pathogens"},{"key":"e_1_3_2_8_2","author":"Australian Government Department of Health","year":"2014","unstructured":"Australian Government Department of Health. 2014. Staphylococcus aureus annual reports prepared by the Australian Group on Antimicrobial Resistance. Australian Government Department of Health, Canberra, Australia. http:\/\/www.health.gov.au\/internet\/main\/publishing.nsf\/content\/cda-mrsa-anrep.htm.","journal-title":"Staphylococcus aureus annual reports prepared by the Australian Group on Antimicrobial Resistance"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.2807\/ese.15.41.19688-en"},{"key":"e_1_3_2_10_2","first-page":"E309","article-title":"Australian Staphylococcus aureus sepsis outcome programme annual report, 2013","volume":"38","author":"Coombs GW","year":"2014","unstructured":"Coombs GW, Nimmo GR, Daly DA, Le TT, Pearson JC, Tan HL, Robinson JO, Collignon PJ, McLaws ML, Turnidge JD. 2014. Australian Staphylococcus aureus sepsis outcome programme annual report, 2013. Commun Dis Intell Q Rep 38:E309\u2013E319.","journal-title":"Commun Dis Intell Q Rep"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/598185"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70876-X"},{"key":"e_1_3_2_13_2","unstructured":"Gilbert DN Moellering RC Jr Eliopoulos GM Chambers HF Saag MS (ed). 2012. The Sanford guide to antimicrobial therapy 42nd ed. Antimicrobial Therapy Inc. Sperryville VA."},{"key":"e_1_3_2_14_2","volume-title":"Therapeutic guidelines: antibiotic, version 15","author":"Antibiotic Expert Groups","year":"2014","unstructured":"Antibiotic Expert Groups. 2014. Therapeutic guidelines: antibiotic, version 15. Therapeutic Guidelines Limited, Melbourne, Australia."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00856-13"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02800-14"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00485-11"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2010.03425.x"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku560"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2010.00507.x"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2010.07.011"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.165564"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-012-1585-y"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu301"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00243-16","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00243-16","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:52:35Z","timestamp":1645476755000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00243-16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1128\/AAC.00243-16"],"URL":"https:\/\/doi.org\/10.1128\/aac.00243-16","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"2016-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}