{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:58:11Z","timestamp":1787507891964,"version":"build-2736575974"},"reference-count":49,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["1283\/3-1"],"award-info":[{"award-number":["1283\/3-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EW116\/2-1"],"award-info":[{"award-number":["EW116\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>\n                    The pathogenic extended-spectrum-beta-lactamase (ESBL)-producing\n                    <jats:named-content content-type=\"genus-species\">Escherichia coli<\/jats:named-content>\n                    lineage ST648 is increasingly reported from multiple origins. Our study of a large and global ST648 collection from various hosts (87 whole-genome sequences) combining core and accessory genomics with functional analyses and\n                    <jats:italic>in vivo<\/jats:italic>\n                    experiments suggests that ST648 is a nascent and generalist lineage, lacking clear phylogeographic and host association signals.\n                  <\/jats:p>","DOI":"10.1128\/aac.00243-19","type":"journal-article","created":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T08:06:23Z","timestamp":1552550783000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":100,"title":["Genomic and Functional Analysis of Emerging Virulent and Multidrug-Resistant\n                    <i>Escherichia coli<\/i>\n                    Lineage Sequence Type 648"],"prefix":"10.1128","volume":"63","author":[{"given":"Katharina","family":"Schaufler","sequence":"first","affiliation":[{"name":"Pharmaceutical Microbiology, Institute of Pharmacy, University of Greifswald, Greifswald, Germany"},{"name":"Institute of Microbiology and Epizootics, Free University Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2225-7267","authenticated-orcid":false,"given":"Torsten","family":"Semmler","sequence":"additional","affiliation":[{"name":"NG 1\u2013Microbial Genomics, Robert Koch Institute, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lothar H.","family":"Wieler","sequence":"additional","affiliation":[{"name":"Robert Koch Institute, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren J.","family":"Trott","sequence":"additional","affiliation":[{"name":"Australian Centre for Antimicrobial Resistance Ecology, School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Pitout","sequence":"additional","affiliation":[{"name":"Calgary Laboratory Services, Diagnostic and Scientific Centre, Calgary, Alberta, Canada"},{"name":"Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisele","family":"Peirano","sequence":"additional","affiliation":[{"name":"Calgary Laboratory Services, Diagnostic and Scientific Centre, Calgary, Alberta, Canada"},{"name":"Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Bonnedahl","sequence":"additional","affiliation":[{"name":"Kalmar County Council, Department of Clinical and Experimental Medicine, Link\u00f6ping University, Link\u00f6ping, Sweden"},{"name":"Department of Infectious Diseases, Kalmar County Council, Kalmar, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Dolejska","sequence":"additional","affiliation":[{"name":"Department of Biology and Wildlife Diseases, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Brno-Kr\u00e1lovo Pole, Czech Republic"},{"name":"CEITEC VFU, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Literak","sequence":"additional","affiliation":[{"name":"Department of Biology and Wildlife Diseases, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Brno-Kr\u00e1lovo Pole, Czech Republic"},{"name":"CEITEC VFU, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Division 13: Nosocomial Pathogens and Antibiotic Resistances, Department of Infectious Diseases, Robert Koch Institute, Wernigerode, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niyaz","family":"Ahmed","sequence":"additional","affiliation":[{"name":"International Center for Diarrheal Disease Research\u2013Bangladesh, Dhaka, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"Grobbel","sequence":"additional","affiliation":[{"name":"Unit Epidemiology, Zoonoses and Antimicrobial Resistance, Department Biological Safety, German Federal Institute for Risk Assessment, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Torres","sequence":"additional","affiliation":[{"name":"Universidad de La Rioja, Area de Bioqu\u00edmica y Biolog\u00eda Molecular, Logro\u00f1o, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"McNally","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Pickard","sequence":"additional","affiliation":[{"name":"The Wellcome Trust Sanger Institute, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6167-1340","authenticated-orcid":false,"given":"Christa","family":"Ewers","sequence":"additional","affiliation":[{"name":"Institute of Hygiene and Infectious Diseases of Animals, Justus Liebig University Giessen, Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Croucher","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, School of Public Health, Imperial College, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jukka","family":"Corander","sequence":"additional","affiliation":[{"name":"The Wellcome Trust Sanger Institute, Cambridge, United Kingdom"},{"name":"Department of Mathematics and Statistics, University of Helsinki, University of Helsinki, Finland"},{"name":"Department of Biostatistics, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Guenther","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Epizootics, Free University Berlin, Berlin, Germany"},{"name":"Pharmaceutical Biology, Institute of Pharmacy, University of Greifswald, Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02162-15"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00347-16"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.216606.116"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt516"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.06025-11"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.022459-0"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01949-16"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006280"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00336"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1322678111"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.10609.1"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2836"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01324-08"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1067\/mlc.2002.121550"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2011.09.006"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01338-09"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2007.00952.x"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001187"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.000367"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13379"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.4.2659-2665.2001"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2002.02802.x"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053039"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.06.016"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01112-10"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00644-19"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2012.00009"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.4161\/viru.26552"},{"key":"e_1_3_3_30_2","volume-title":"Performance standards for antimicrobial disk and dilution susceptibility tests for bacteria isolated from animals; approved standard","author":"Clinical and Laboratory Standards Institute","year":"2008","unstructured":"Clinical and Laboratory Standards Institute. 2008. Performance standards for antimicrobial disk and dilution susceptibility tests for bacteria isolated from animals; approved standard, 3rd ed. Clinical and Laboratory Standards Institute, Wayne, PA.","edition":"3"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.074492.107"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq269"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu153"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp352"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.129684.111"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu033"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mbs.2006.09.015"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btx610"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/sysbio\/syv068"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv421"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks261"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.03617-13"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-10-421"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-12-402"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-4557-x"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.173.17.5298-5307.1991"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/msb4100049"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90612-9"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mst028"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00243-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00243-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T16:28:28Z","timestamp":1645460908000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00243-19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1128\/AAC.00243-19"],"URL":"https:\/\/doi.org\/10.1128\/aac.00243-19","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"2019-02-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00243-19"}}