{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:59:46Z","timestamp":1792468786931,"version":"4.5.0"},"reference-count":25,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The efficacies of many antimicrobial peptides are greatly reduced under high salt concentrations, therefore limiting their use as pharmaceutical agents. Here, we describe a strategy to boost salt resistance and serum stability of short antimicrobial peptides by adding the nonnatural bulky amino acid \u03b2-naphthylalanine to their termini. The activities of the short salt-sensitive tryptophan-rich peptide S1 were diminished at high salt concentrations, whereas the activities of its \u03b2-naphthylalanine end-tagged variants were less affected.<\/jats:p>","DOI":"10.1128\/aac.00252-13","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T00:58:59Z","timestamp":1369789139000},"page":"4050-4052","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":109,"title":["Boosting Salt Resistance of Short Antimicrobial Peptides"],"prefix":"10.1128","volume":"57","author":[{"given":"Hung-Lun","family":"Chu","sequence":"first","affiliation":[{"name":"Institute of Biotechnology and Department of Medical Science, National Tsing Hua University, Hsinchu, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Yuan","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology and Department of 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