{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:50:57Z","timestamp":1791053457055,"version":"4.1.0"},"reference-count":32,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The effects of acid, oxgall, and H\n            <jats:sub>2<\/jats:sub>\n            O\n            <jats:sub>2<\/jats:sub>\n            on susceptibilities to antibiotics and nisin were examined for 13 strains of bifidobacteria. Susceptibilities to ampicillin, cloxacillin, penicillin, vancomycin, kanamycin, neomycin, paramomycin, streptomycin, chloramphenicol, erythromycin, tetracycline, and nisin A were assayed by a microdilution broth method. Acid-, oxgall- and H\n            <jats:sub>2<\/jats:sub>\n            O\n            <jats:sub>2<\/jats:sub>\n            -stressed variants were produced and assayed. Exposure to a pH of 2.0 for 60 min reduced susceptibilities to cloxacillin and nisin A but increased susceptibilities to ampicillin, vancomycin, aminoglycosides, chloramphenicol, and erythromycin in a strain-dependent manner. Exposure to oxgall (0.3%) for 90 min increased susceptibilities to cell wall-directed antibiotics and aminoglycosides but increased resistances to tetracycline and nisin A. Oxidative stress increased the susceptibilities of 70% of the strains to ampicillin and chloramphenicol, of 50% of the strains to cloxacillin and tetracycline, and of 40% of the strains to erythromycin but did not affect susceptibilities to vancomycin, kanamycin, and nisin A. This study shows that exposure of bifidobacteria to stressful conditions resembling those in the gastrointestinal tract may substantially modify their susceptibilities to antibiotics and may thus affect their probiotic capacities, especially when they are used for the management of intestinal infections and antibiotic-associated diarrhea.\n          <\/jats:p>","DOI":"10.1128\/aac.00261-06","type":"journal-article","created":{"date-parts":[[2006,12,20]],"date-time":"2006-12-20T18:32:51Z","timestamp":1166639571000},"page":"169-174","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":40,"title":["Antibiotic Susceptibility Profile of Bifidobacteria as Affected by Oxgall, Acid, and Hydrogen Peroxide Stress"],"prefix":"10.1128","volume":"51","author":[{"given":"E.","family":"Kheadr","sequence":"first","affiliation":[{"name":"Nutraceuticals and Functional Foods Institute (INAF), Universite\u0301 Laval, Que\u0301bec, PQ, Canada, G1K 7P4"},{"name":"Department of Dairy Science and Technology, Faculty of Agriculture, University of Alexandria, Alexandria, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Dabour","sequence":"additional","affiliation":[{"name":"Nutraceuticals and Functional Foods Institute (INAF), Universite\u0301 Laval, Que\u0301bec, PQ, Canada, G1K 7P4"},{"name":"Department of Dairy Science and Technology, Faculty of Agriculture, University of Alexandria, Alexandria, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Le Lay","sequence":"additional","affiliation":[{"name":"Nutraceuticals and Functional Foods Institute (INAF), Universite\u0301 Laval, Que\u0301bec, PQ, Canada, G1K 7P4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lacroix","sequence":"additional","affiliation":[{"name":"Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, ETH Zentrum, LFO F18 CH-8092 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Fliss","sequence":"additional","affiliation":[{"name":"Nutraceuticals and Functional Foods Institute (INAF), Universite\u0301 Laval, Que\u0301bec, PQ, Canada, G1K 7P4"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/12.2.163"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.14.3.371"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-765X.1990.tb00148.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365549109023408"},{"key":"e_1_3_2_6_2","first-page":"3","volume":"3","year":"2000","unstructured":"Cabiscol, E., J. Tamarit, and J. Ros. 2000. Oxidative stress in bacteria and protein damage by reactive oxygen species. Int. Microbiol.3:3-8.","journal-title":"Int. Microbiol."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2672.1998.00407.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X-63.10.1369"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1605(02)00254-4"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0958-6946(96)00046-5"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/mr.51.3.341-350.1987"},{"key":"e_1_3_2_12_2","first-page":"223","volume":"27","year":"1993","unstructured":"Duffy, L. C., M. A. Zielezny, M. Riepenhoff-Talty, D. Dryia, S. Sayahtaheri-Altaie, E. Griffiths, D. Ruffin, H. Barrett, J. Rossman, and P. L. Ogra. 1993. Effectiveness of Bifidobacterium bifidum in experimentally induced MRV infection: dietary implications in formulas for newborns. Endocrine Regulations27:223-229.","journal-title":"Endocrine Regulations"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03530350052034"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2003.07.010"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90490-0"},{"key":"e_1_3_2_16_2","first-page":"20","year":"1985","unstructured":"Halliwell, B., and J. M. Gutteridge. 1985. Free radicals in biology and medicine, p. 20-64. Clarendon Press, Oxford, United Kingdom.","journal-title":"Free radicals in biology and medicine"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.176.1.260-264.1994"},{"key":"e_1_3_2_18_2","first-page":"74","volume":"45","year":"1991","unstructured":"Hughes, D. B., and D. G. Hoover. 1991. Bifidobacteria: their potential for use in American dairy products. Food Technol.45:74-79.","journal-title":"Food Technol."},{"key":"e_1_3_2_19_2","first-page":"149","volume":"3","year":"1997","unstructured":"Ishibashi, N., T. Yaeshima, and H. Hayasawa. 1997. Bifidobacteria: their significance in human intestinal health. Malays. J. Nutr.3:149-156.","journal-title":"Malays. J. Nutr."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idairyj.2004.04.010"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf971041q"},{"key":"e_1_3_2_22_2","first-page":"1206","volume":"4","year":"2001","unstructured":"Kot, E., Y. Murad, and A. Bezkorovainy. 2001. The effect of nisin on the physiology of Bifidobacterium thermophilum. J. Food Prot.4:1206-1210.","journal-title":"J. Food Prot."},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(93)77553-0"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0315-5463(90)70197-6"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.1.24-29.2000"},{"key":"e_1_3_2_26_2","unstructured":"National Committee for Clinical Laboratory Standards. 1991. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically 2nd ed. Approved standard M7-A2. NCCLS Villanova PA."},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2004.01.003"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/55.1.78"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.26.10.2064-2068.1988"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.4.543"},{"key":"e_1_3_2_31_2","unstructured":"Tissier H. 1900. Recherche sur la flore intestinale des nousons (\u00e9tat normale et pathologique). Ph.D. thesis. University of Paris School of Medicine Paris France."},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1472-765x.2000.00764.x"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.12938\/bifidus1982.10.1_11"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00261-06","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00261-06","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T19:23:15Z","timestamp":1645471395000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00261-06"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1128\/AAC.00261-06"],"URL":"https:\/\/doi.org\/10.1128\/aac.00261-06","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1]]},"assertion":[{"value":"2006-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-08-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}