{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T03:37:36Z","timestamp":1789529856743,"version":"build-2803163510"},"reference-count":33,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Pfizer Pharma Germany","award":["WI186302"],"award-info":[{"award-number":["WI186302"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Patients with hematologic malignancies as well as allogeneic hematopoietic stem cell transplantation (HSCT) patients are at high risk for invasive aspergillosis. Here, we report a culture- and autopsy-proven fatal invasive aspergillosis in an allogeneic HSTC patient which he developed despite posaconazole prophylaxis. The agent was determined to be an azole-resistant\n            <jats:named-content content-type=\"genus-species\">Aspergillus fumigatus<\/jats:named-content>\n            strain bearing the\n            <jats:italic>cyp51A<\/jats:italic>\n            mutation combination TR\n            <jats:sub>46<\/jats:sub>\n            Y121F M172I T289A. At increasing frequency, the azole resistance of\n            <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n            is being reported globally, limiting treatment options and complicating regimens.\n          <\/jats:p>","DOI":"10.1128\/aac.00270-17","type":"journal-article","created":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T15:45:18Z","timestamp":1500997518000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Progressive Dispersion of Azole Resistance in Aspergillus fumigatus: Fatal Invasive Aspergillosis in a Patient with Acute Myeloid Leukemia Infected with an A. fumigatus Strain with a\n            <i>cyp51A<\/i>\n            TR\n            <sub>46<\/sub>\n            Y121F M172I T289A Allele"],"prefix":"10.1128","volume":"61","author":[{"given":"Susann","family":"R\u00f6\u00dfler","sequence":"first","affiliation":[{"name":"Institute of Medical Microbiology and Hygiene, Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1534-440X","authenticated-orcid":false,"given":"Oliver","family":"Bader","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"St\u00f6lzel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Hospital Carl Gustav at the Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Sommer","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospital Carl Gustav at the Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Spiess","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, Hematology and Oncology, Mannheim University Hospital, University of Heidelberg, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Geibel","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Buchheidt","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, Hematology and Oncology, Mannheim University Hospital, University of Heidelberg, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Gro\u00df","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Baretton","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospital Carl Gustav at the Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enno","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hygiene, Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Ostrosky-Zeichner","sequence":"additional","affiliation":[{"name":"Laboratory of Mycology Research, Center for Antimicrobial Resistance and Microbial Genomics, McGovern Medical School, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.142"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-1867-1"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2008.02086.x"},{"key":"e_1_3_2_5_2","unstructured":"EUCAST. 12 August 2014 posting date. 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