{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T08:46:00Z","timestamp":1759826760466,"version":"3.41.2"},"reference-count":38,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100007114","name":"African Institute for Mathematical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007114","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["129119"],"award-info":[{"award-number":["129119"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["127567"],"award-info":[{"award-number":["127567"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2022,9,20]]},"abstract":"<jats:p>Physiologically based pharmacokinetic (PBPK) models have gained in popularity in the last decade in both drug development and regulatory science. PBPK models differ from classical pharmacokinetic models in that they include specific compartments for tissues involved in exposure, toxicity, biotransformation, and clearance processes connected by blood flow.<\/jats:p>","DOI":"10.1128\/aac.00274-22","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T13:11:47Z","timestamp":1658236307000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["A Comparative Analysis of Physiologically Based Pharmacokinetic Models for Human Immunodeficiency Virus and Tuberculosis Infections"],"prefix":"10.1128","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1292-7503","authenticated-orcid":true,"given":"Sinenhlanhla","family":"Mtshali","sequence":"first","affiliation":[{"name":"Department of Mathematics and Applied Mathematics, University of Johannesburg, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byron A.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Applied Mathematics, University of Johannesburg, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1063\/5.0058345"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-015-0253-7"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.2217\/fvl.13.67"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.936"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-017-0976-0"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40495-016-0059-9"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12234"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200645050-00006"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2012.12.001"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2016.1184940"},{"key":"e_1_3_4_12_2","first-page":"16","article-title":"Hepatotoxicity from first line antiretroviral therapy: an experience from a resource limited setting","volume":"11","author":"Kalyesubula R","year":"2011","unstructured":"Kalyesubula R, Kagimu M, Opio KC, Kiguba R, Semitala CF, Schlech WF, Katabira ET. 2011. Hepatotoxicity from first line antiretroviral therapy: an experience from a resource limited setting. African Health Sci 11:16\u201323.","journal-title":"African Health Sci"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-023140"},{"key":"e_1_3_4_14_2","first-page":"430","article-title":"Drug-induced liver injury in HIV patients","volume":"2","author":"Neff GW","year":"2006","unstructured":"Neff GW, Jayaweera D, Sherman KE. 2006. Drug-induced liver injury in HIV patients. Gastroenterol Hepatol (NY) 2:430\u2013437.","journal-title":"Gastroenterol Hepatol (NY)"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2016.1188398"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2587094"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-016-9646-0"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.2147\/HIV.S39665"},{"key":"e_1_3_4_19_2","volume-title":"Pharmacology in drug discovery and development: understanding drug response.","author":"Kenakin T","year":"2016","unstructured":"Kenakin T. 2016. Pharmacology in drug discovery and development: understanding drug response. Academic Press, New York."},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/jfb.12796"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01598-10"},{"key":"e_1_3_4_22_2","volume-title":"An introduction to the conjugate gradient method without the agonizing pain.","author":"Shewchuk JR","year":"1994","unstructured":"Shewchuk JR. 1994. An introduction to the conjugate gradient method without the agonizing pain. School of Copmuter Science, Carnegie Mellon University, Pittsburgh, PA."},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1086\/515174"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044793"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31820c9e3c"},{"key":"e_1_3_4_26_2","unstructured":"European Medicines Agency. 2014. Annex I. Summary of product characteristics section 4 2. https:\/\/ec.europa.eu\/health\/documents\/community-register\/2014\/20140428126881\/anx_126881_en.pdf."},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199815000-00005"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1530\/ERP-17-0024"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00031-16"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01567-12"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2016.08.007"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-5-29"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2017.0254"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00684-16"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering4020040"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.3390\/mca23020027"},{"key":"e_1_3_4_37_2","unstructured":"Woods BF. 1989. Numerical instabilities in finite-difference models of ordinary differential equations p 1\u201312. Robert W. Woodruff Library Atlanta Germany."},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnsns.2018.07.009"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1177\/074823379701300401"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00274-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00274-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T13:17:02Z","timestamp":1663679822000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.00274-22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,20]]},"references-count":38,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9,20]]}},"alternative-id":["10.1128\/aac.00274-22"],"URL":"https:\/\/doi.org\/10.1128\/aac.00274-22","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"type":"print","value":"0066-4804"},{"type":"electronic","value":"1098-6596"}],"subject":[],"published":{"date-parts":[[2022,9,20]]},"assertion":[{"value":"2022-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00274-22"}}