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Bedaquiline (B), delamanid (D), and pretomanid (P) are used in combination regimens with other anti-TB drugs for MDR-TB; however, agents with novel mechanisms of action are needed. DprE1 inhibitor quabodepistat (Q) was developed for combination use. In this study, Q alone or in combination with human-equivalent doses of D and\/or B was evaluated in a marmoset TB model using\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      imaging, with terminal bacterial counts from all lung lesions. Marmosets were infected with H37Rv\n                      <jats:italic toggle=\"yes\">Mycobacterium tuberculosis<\/jats:italic>\n                      and allowed to develop the disease for 7 weeks. They were then administered a pre-treatment\n                      <jats:sup>18<\/jats:sup>\n                      F-fluorodeoxyglucose positron emission tomography\/computed tomography (18F-FDG PET\/CT) scan and randomized into seven treatment groups (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 5\/group). At 2 weeks, the quabodepistat-treated groups showed a significant reduction in lesion volume compared to those without the agent in a post hoc analysis. After 2 months, the animals were euthanized, and the bacterial burden and histology were assessed. Marmosets treated with all agents showed reduced lung disease on PET\/CT (&gt;70%) compared to their pre-treatment disease volume. B reduced extrapulmonary bacteria more significantly than Q or D. Cavities and necrotic lesions from DBQ-treated animals had lower bacterial burdens than lesions treated with any of the single-agent or two-agent combinations. In a preliminary comparison, DBQ showed no statistically detectable difference from the standard-of-care regimen isoniazid-rifampicin-pyrazinamide-ethambutol (HRZE). Additionally, the activities of D and P monotherapies were similar in this model. The evaluation of these agents in the marmoset TB model supports further investigation of Q as a component of shorter TB regimens.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.00280-26","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:01:36Z","timestamp":1789567296000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of quabodepistat alone and in combination with delamanid and bedaquiline against\n                    <i>Mycobacterium tuberculosis<\/i>\n                    in an NHP model evaluated by [\n                    <sup>18<\/sup>\n                    F] FDG PET\/CT and bacterial burden"],"prefix":"10.1128","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6074-9521","authenticated-orcid":false,"given":"L. 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