{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:57:26Z","timestamp":1790773046986,"version":"4.1.0"},"reference-count":70,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative","doi-asserted-by":"publisher","award":["115525"],"award-info":[{"award-number":["115525"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2020,5,21]]},"abstract":"<jats:p>\n            The Cpx stress response is widespread among\n            <jats:italic>Enterobacteriaceae<\/jats:italic>\n            . We previously reported a mutation in\n            <jats:italic>cpxA<\/jats:italic>\n            in a multidrug-resistant strain of\n            <jats:named-content content-type=\"genus-species\">Klebsiella aerogenes<\/jats:named-content>\n            isolated from a patient treated with imipenem. This mutation yields a single-amino-acid substitution (Y144N) located in the periplasmic sensor domain of CpxA. In this work, we sought to characterize this mutation in\n            <jats:named-content content-type=\"genus-species\">Escherichia coli<\/jats:named-content>\n            by using genetic and biochemical approaches.\n          <\/jats:p>","DOI":"10.1128\/aac.00291-20","type":"journal-article","created":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T13:27:03Z","timestamp":1585661223000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":59,"title":["Complex Response of the CpxAR Two-Component System to \u03b2-Lactams on Antibiotic Resistance and Envelope Homeostasis in\n            <i>Enterobacteriaceae<\/i>"],"prefix":"10.1128","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1444-7511","authenticated-orcid":false,"given":"Muriel","family":"Masi","sequence":"first","affiliation":[{"name":"UMR_MD1, U-1261, Aix-Marseille University, INSERM, IRBA, MCT, Facult\u00e9 de Pharmacie, Marseille, 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