{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:32:49Z","timestamp":1790033569136,"version":"4.0.1"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Leishmaniasis is among the world's most neglected diseases. Currently available drugs for treatment present drawbacks, urging the need for more effective, safer, and cheaper drugs. A small library of artemisinin-derived trioxanes and synthetic trioxolanes was tested against promastigote and intramacrophage amastigote forms of\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Leishmania infantum<\/jats:named-content>\n                    . The trioxolanes LC50 and LC95 presented the best activity and safety profiles, showing potential for further studies in the context of leishmanial therapy. Our results indicate that the compounds tested exhibit peroxide-dependent activity.\n                  <\/jats:p>","DOI":"10.1128\/aac.00298-15","type":"journal-article","created":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T11:24:53Z","timestamp":1432725893000},"page":"5032-5035","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":36,"title":["<i>In Vitro<\/i>\n                    Susceptibility of Leishmania infantum to Artemisinin Derivatives and Selected Trioxolanes"],"prefix":"10.1128","volume":"59","author":[{"given":"Sofia","family":"Cortes","sequence":"first","affiliation":[{"name":"Global Health and Tropical Medicine (GHTM), Unidade de Ensino e Investiga\u00e7\u00e3o de Parasitologia M\u00e9dica, Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa (UNL), Lisbon, Portugal"},{"name":"Centro de Mal\u00e1ria e Outras Doen\u00e7as Tropicais, IHMT, UNL, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreia","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Global Health and Tropical Medicine (GHTM), Unidade de Ensino e Investiga\u00e7\u00e3o de Parasitologia M\u00e9dica, Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa (UNL), Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edlia I. L.","family":"Cabral","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias do Mar (CCMAR), Universidade do Algarve (UAlg), Campus de Gambelas, Faro, Portugal"},{"name":"Departamento de Qu\u00edmica e Farm\u00e1cia, UAlg, Campus de Gambelas, Faro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Lopes","sequence":"additional","affiliation":[{"name":"Global Health and Tropical Medicine (GHTM), Unidade de Ensino e Investiga\u00e7\u00e3o de Parasitologia M\u00e9dica, Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa (UNL), Lisbon, Portugal"},{"name":"Departamento Ci\u00eancias Biom\u00e9dicas e Medicina, UAlg, Campus de Gambelas, Faro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenea","family":"Campino","sequence":"additional","affiliation":[{"name":"Global Health and Tropical Medicine (GHTM), Unidade de Ensino e Investiga\u00e7\u00e3o de Parasitologia M\u00e9dica, Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa (UNL), Lisbon, Portugal"},{"name":"Departamento de Qu\u00edmica e Farm\u00e1cia, UAlg, Campus de Gambelas, Faro, Portugal"},{"name":"Departamento Ci\u00eancias Biom\u00e9dicas e Medicina, UAlg, Campus de Gambelas, Faro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria L. 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