{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T16:52:08Z","timestamp":1761929528625},"reference-count":20,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>The susceptibilities of vertilmicin and seven reference aminoglycosides to modifications by six recombinant aminoglycoside-modifying enzymes, AAC(6\u2032)-Ie, APH(2\u2032\u2032)-Ia, AAC(6\u2032)-Ie-APH(2\u2032\u2032)-Ia, ANT(2\u2032\u2032)-Ia, AAC(6\u2032)-Ib, and AAC(6\u2032)-Ib-cr, were studied by coupled spectrophotometric assays in microtiter plates. In comparison to other aminoglycosides, the susceptibility of vertilmicin was 45.8- to 250.0-fold lower for AAC(6\u2032)-Ie acetylation, 39.2- to 116.7-fold lower for AAC(6\u2032)-Ie-APH(2\u2032\u2032)-Ia acetylation, and 1.8- to 7.5-fold lower for ANT(2\u2032\u2032)-Ia adenylation (except that shown by amikacin) while relatively comparable for AAC(6\u2032)-Ib acetylation, AAC(6\u2032)-Ib-cr acetylation, APH(2\u2032\u2032)-Ia phosphorylation, and AAC(6\u2032)-Ie-APH(2\u2032\u2032)-Ia phosphorylation.<\/jats:p>","DOI":"10.1128\/aac.00300-11","type":"journal-article","created":{"date-parts":[[2011,6,7]],"date-time":"2011-06-07T01:54:15Z","timestamp":1307411655000},"page":"3950-3953","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Susceptibility of Vertilmicin to Modifications by Three Types of Recombinant Aminoglycoside-Modifying Enzymes"],"prefix":"10.1128","volume":"55","author":[{"given":"Min","family":"Yuan","sequence":"first","affiliation":[{"name":"Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Han","sequence":"additional","affiliation":[{"name":"Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong-Ran","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences 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