{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:14:31Z","timestamp":1790381671790,"version":"4.1.0"},"reference-count":45,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T00:00:00Z","timestamp":1603152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["201806100109"],"award-info":[{"award-number":["201806100109"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2020,10,20]]},"abstract":"<jats:p>\n            <jats:named-content content-type=\"genus-species\">Lomentospora prolificans<\/jats:named-content>\n            is an opportunistic fungal pathogen with low susceptibility to current antifungal drugs. Here, we tested the\n            <jats:italic>in vitro<\/jats:italic>\n            susceptibility of 8 drugs against 42 clinical\n            <jats:named-content content-type=\"genus-species\">L. prolificans<\/jats:named-content>\n            isolates. All isolates showed high MICs to voriconazole (MIC\n            <jats:sub>90<\/jats:sub>\n            &gt;16\u2009\u03bcg\/ml), itraconazole (MIC\n            <jats:sub>90<\/jats:sub>\n            &gt;16\u2009\u03bcg\/ml), posaconazole (MIC\n            <jats:sub>90<\/jats:sub>\n            &gt;16\u2009\u03bcg\/ml), isavuconazole (MIC\n            <jats:sub>90<\/jats:sub>\n            &gt;16\u2009\u03bcg\/ml), amphotericin B (MIC\n            <jats:sub>90<\/jats:sub>\n            &gt;16\u2009\u03bcg\/ml), and terbinafine (MIC\n            <jats:sub>90<\/jats:sub>\n            &gt;64\u2009\u03bcg\/ml) and high minimum effective concentrations (MECs) to micafungin (MEC\n            <jats:sub>90<\/jats:sub>\n            &gt;8\u2009\u03bcg\/ml), with the exception of miltefosine showing an MIC\n            <jats:sub>90<\/jats:sub>\n            value of 4\u2009\u03bcg\/ml.\n          <\/jats:p>","DOI":"10.1128\/aac.00318-20","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T13:01:17Z","timestamp":1597323677000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":34,"title":["Antifungal Susceptibility Profiles and Drug Resistance Mechanisms of Clinical Lomentospora prolificans Isolates"],"prefix":"10.1128","volume":"64","author":[{"given":"Yongqin","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China"},{"name":"Division of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Grossman","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa","family":"Totten","sequence":"additional","affiliation":[{"name":"Division of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warda","family":"Memon","sequence":"additional","affiliation":[{"name":"Microbiology Laboratory, Johns Hopkins Hospital, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Microbiology Laboratory, Johns Hopkins Hospital, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1166-2563","authenticated-orcid":false,"given":"Sean X.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"},{"name":"Microbiology Laboratory, Johns Hopkins Hospital, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/1040841X.2018.1514366"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04423-8"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780802524506"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00039-07"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.1.106-117.2003"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.8.3498-3500.2005"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.44.2.470-472.2000"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2007.00240.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0507.2003.00878.x"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365540600786564"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2016.12.020"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00312-18"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03212-14"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.000019"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt282"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2017.06.009"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2017.06.018"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02599-17"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12831"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00020-09"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01811-10"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2019.113385"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2015.06.001"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.7.2747-2750.2004"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks275"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.48.3.852-859.2004"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01614-17"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-002-0877-z"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01382-17"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myx159"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174885"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00392-19"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky517"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00517-11"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00095-16"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01599-09"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01358-10"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02101-16"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00543-19"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz121"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2019.05.005"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00208-19"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00779-19"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg301"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1534\/g3.117.300107"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00318-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00318-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:35:27Z","timestamp":1645479327000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00318-20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,20]]},"references-count":45,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,10,20]]}},"alternative-id":["10.1128\/AAC.00318-20"],"URL":"https:\/\/doi.org\/10.1128\/aac.00318-20","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,20]]},"assertion":[{"value":"2020-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00318-20"}}