{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:54:16Z","timestamp":1791986056989,"version":"4.4.0"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"HOROS Doctoral Program","award":["W1253-B24"],"award-info":[{"award-number":["W1253-B24"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2025,6,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      SF001, a next-generation polyene drug, offers broad-spectrum fungicidal activity with less potential for toxicity than classic polyene amphotericin B (AmB). This study compared the\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      activity of SF001 and amphotericin B against\n                      <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Aspergillus<\/jats:italic>\n                      species. SF001 demonstrated activity comparable to AmB against\n                      <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                      isolates (MIC\n                      <jats:sub>50\/90<\/jats:sub>\n                      of 0.25\/1 and 0.5\/0.5 mg\/L, respectively). However,\n                      <jats:italic toggle=\"yes\">Aspergillus<\/jats:italic>\n                      isolates exhibited higher susceptibility to SF001 than AmB (MIC\n                      <jats:sub>50\/90<\/jats:sub>\n                      of 0.5\/1 and 1\/4 mg\/L, respectively), notably including AmB-resistant species.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.00322-25","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T09:03:47Z","timestamp":1745312627000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["<i>In vitro<\/i>\n                    activity of SF001: a next-generation polyene versus amphotericin B"],"prefix":"10.1128","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7518-7795","authenticated-orcid":true,"given":"Roya","family":"Vahedi-Shahandashti","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/054pv6659","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck","place":["Innsbruck, Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2946-7785","authenticated-orcid":true,"given":"Cornelia","family":"Lass-Fl\u00f6rl","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/054pv6659","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck","place":["Innsbruck, Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00692-8"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2010.06.002"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-020-00382-7"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof10040278"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof6040321"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12469"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2019.103247"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001692"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkac351"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkac352"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof10120871"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06710-4"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01631-23"},{"key":"e_1_3_3_15_2","unstructured":"Guinea J Meletiadis J Arikan-Akdagli S Muehlethaler K Kahlmeter G ArendrupMC. 2022. Eucast definitive document E.DEF 9.4."},{"key":"e_1_3_3_16_2","unstructured":"Guinea J Meletiadis J Arikan-Akdagli S Giske C Muehlethaler K Kahlmeter G ArendrupMC. 2023. Eucast definitive document E.DEF 7.4."},{"key":"e_1_3_3_17_2","unstructured":"The European Committee on Antimicrobial Susceptibility Testing. 2023. Routine and extended internal quality control for MIC determination and agar dilution for yeasts moulds and dermatophytes as recommended by EUCAST. Version 7.0 2023. http:\/\/www.eucast.org."},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycmed.2022.101310"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2012.684154"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.4066\/AMJ.2011.905"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.1998.tb00949.x"},{"key":"e_1_3_3_22_2","unstructured":"The European Committee on Antimicrobial Susceptibility Testing. 2024. Overview of antifungal ECOFFs and clinical breakpoints for yeasts moulds and dermatophytes using the EUCAST E.Def 7.4 E.Def 9.4 and E.Def 11.0 procedures. Version 5.0 2024. http:\/\/www.eucast.org."},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof6040213"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.46"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof2030025"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00322-25","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00322-25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T09:01:08Z","timestamp":1749027668000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.00322-25"}},"subtitle":[],"editor":[{"given":"Andreas H.","family":"Groll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,6,4]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6,4]]}},"alternative-id":["10.1128\/aac.00322-25"],"URL":"https:\/\/doi.org\/10.1128\/aac.00322-25","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,4]]},"assertion":[{"value":"2025-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00322-25"}}