{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:50:13Z","timestamp":1791237013675,"version":"4.1.0"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We compared the population structure and drug resistance patterns of the\n            <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n            strains currently circulating in the Beijing area of China. One hundred thirteen of 123 strains belonged to the Beijing family genotypes defined by spoligotyping. The Beijing genotype strains were further subdivided into old and modern sublineages on the basis of NTF locus analysis. A stronger association with resistance to the more recently introduced antituberculosis drugs has been observed for old versus modern strains of the Beijing genotype, suggesting that its different sublineages may differ in their mechanisms of adaptation to drug selective pressure.\n          <\/jats:p>","DOI":"10.1128\/aac.00324-06","type":"journal-article","created":{"date-parts":[[2006,7,26]],"date-time":"2006-07-26T18:17:58Z","timestamp":1153937878000},"page":"2820-2823","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":60,"title":["Evolution of Drug Resistance in Different Sublineages of\n            <i>Mycobacterium tuberculosis<\/i>\n            Beijing Genotype"],"prefix":"10.1128","volume":"50","author":[{"given":"Igor","family":"Mokrousov","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Microbiology, St. Petersburg Pasteur Institute, 197101 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei Wei","family":"Jiao","sequence":"additional","affiliation":[{"name":"Public Central Laboratory, Beijing Pediatric Institute, Beijing Children's Hospital Affiliated to Capital University of Medical Sciences, 56 Nan Li Shi Road, Xi Cheng District, Beijing 100045, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui Zhi","family":"Sun","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Beijing Chest Hospital, Wenquan Town, Haidian District, Beijing 100095, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia Wen","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Beijing Chest Hospital, Wenquan Town, Haidian District, Beijing 100095, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violeta","family":"Valcheva","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Bacteria, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mo","family":"Li","sequence":"additional","affiliation":[{"name":"Public Central Laboratory, Beijing Pediatric Institute, Beijing Children's Hospital Affiliated to Capital University of Medical Sciences, 56 Nan Li Shi Road, Xi Cheng District, Beijing 100045, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Narvskaya","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Microbiology, St. Petersburg Pasteur Institute, 197101 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Dong","family":"Shen","sequence":"additional","affiliation":[{"name":"Public Central Laboratory, Beijing Pediatric Institute, Beijing Children's Hospital Affiliated to Capital University of Medical Sciences, 56 Nan Li Shi Road, Xi Cheng District, Beijing 100045, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(01)02277-6"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-6-23"},{"key":"e_1_3_2_4_2","first-page":"28","volume":"18","year":"1996","unstructured":"Chinese Anti-tuberculosis Association. 1996. The laboratory science procedure of diagnostic bacteriology in tuberculosis. Zhong Guo Fang Lao Za Zhi18:28-31.","journal-title":"Zhong Guo Fang Lao Za Zhi"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-6-134"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2004.04.013"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1069771"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1201.041214"},{"key":"e_1_3_2_9_2","unstructured":"Gilman J. and M. Myatt. 1998. EpiCalc 2000. Version 1.02. Brixton Books London United Kingdom."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0808.020002"},{"key":"e_1_3_2_11_2","first-page":"87s","volume":"36","year":"2002","unstructured":"Iseman, M. D. 2002. Tuberculosis therapy: past, present and future. Eur. Respir. J.36:87s-94s.","journal-title":"Eur. Respir. 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