{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T02:46:31Z","timestamp":1779936391867,"version":"3.53.1"},"reference-count":11,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T00:00:00Z","timestamp":1608076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2020,12,16]]},"abstract":"<jats:p>\n            Mutations in\n            <jats:italic>ERG11<\/jats:italic>\n            were detected by gene sequencing and amino acid alignment in 18\n            <jats:named-content content-type=\"genus-species\">Candida tropicalis<\/jats:named-content>\n            strains with different degrees of sensitivity to voriconazole (VRC).\n            <jats:italic>ERG11<\/jats:italic>\n            expression, sterol content, and membrane permeability were also evaluated. We report three missense mutations in\n            <jats:italic>ERG11<\/jats:italic>\n            that resulted in resistance to VRC. The transcriptional levels of\n            <jats:italic>ERG11<\/jats:italic>\n            as well as the ergosterol content and membrane permeability demonstrated no correlation to only a slight correlation with the obtained MIC values, but the data did suggest a tendency toward such a correlation.\n          <\/jats:p>","DOI":"10.1128\/aac.00325-20","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T14:58:21Z","timestamp":1603119501000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["<i>ERG11<\/i>\n            Polymorphism in Voriconazole-Resistant Candida tropicalis: Weak Role of\n            <i>ERG11<\/i>\n            Expression, Ergosterol Content, and Membrane Permeability"],"prefix":"10.1128","volume":"65","author":[{"given":"Patricia","family":"Navarro-Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Unitat de Microbiologia, Facultat de Medicina i Ci\u00e8ncies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loida","family":"L\u00f3pez-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Unitat de Microbiologia, Facultat de Medicina i Ci\u00e8ncies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adela","family":"Martin-Vicente","sequence":"additional","affiliation":[{"name":"Unitat de Microbiologia, Facultat de Medicina i Ci\u00e8ncies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Guarro","sequence":"additional","affiliation":[{"name":"Unitat de Microbiologia, Facultat de Medicina i Ci\u00e8ncies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0765-6403","authenticated-orcid":false,"given":"Javier","family":"Capilla","sequence":"additional","affiliation":[{"name":"Unitat de Microbiologia, Facultat de Medicina i Ci\u00e8ncies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.riam.2013.10.001"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.2.668-679.2005"},{"key":"e_1_3_1_4_2","volume-title":"Reference method for broth dilution antifungal susceptibility testing of yeast; approved standard\u20143rd ed","author":"Clinical and Laboratory Standards Institute (CLSI)","year":"2008","unstructured":"Clinical and Laboratory Standards Institute (CLSI). 2008. Reference method for broth dilution antifungal susceptibility testing of yeast; approved standard\u20143rd ed. CLSI document M27\u20133A. 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