{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:51:58Z","timestamp":1765486318356,"version":"3.41.2"},"reference-count":36,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>\n            Ceftolozane-tazobactam (C\/T) is a novel cephalosporin with\n            <jats:italic>in vitro<\/jats:italic>\n            activity against\n            <jats:named-content content-type=\"genus-species\">Pseudomonas aeruginosa<\/jats:named-content>\n            that is resistant to extended-spectrum penicillins and antipseudomonal cephalosporins. In order to assess the antimicrobial effect of C\/T in treatment of\n            <jats:italic>Pseudomonas<\/jats:italic>\n            pneumonia, we investigated the pharmacokinetics and efficacy of C\/T in persistently neutropenic rabbits.\n            <jats:italic>Pseudomonas<\/jats:italic>\n            pneumonia was established by direct endotracheal inoculation.\n          <\/jats:p>","DOI":"10.1128\/aac.00344-19","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T13:15:11Z","timestamp":1560950111000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Ceftolozane-Tazobactam in the Treatment of Experimental Pseudomonas aeruginosa Pneumonia in Persistently Neutropenic Rabbits: Impact on Strains with Genetically Defined Mechanisms of 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