{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:54:24Z","timestamp":1791176064159,"version":"4.1.0"},"reference-count":19,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Determinations of doxycycline 50% inhibitory concentrations (IC\n            <jats:sub>50<\/jats:sub>\n            ) for 620 isolates from northwest Thailand were performed via the isotopic method, and the data were analyzed by the Bayesian method and distributed into two populations (mean IC\n            <jats:sub>50<\/jats:sub>\n            s of 13.15 \u03bcM and 31.60 \u03bcM). There was no significant difference between the group with low IC\n            <jats:sub>50<\/jats:sub>\n            s versus the group with high IC\n            <jats:sub>50<\/jats:sub>\n            s with regard to copy numbers of the\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Plasmodium falciparum<\/jats:named-content>\n            <jats:italic>tetQ<\/jats:italic>\n            (\n            <jats:italic>pftetQ<\/jats:italic>\n            ) gene (\n            <jats:italic>P<\/jats:italic>\n            = 0.11) or\n            <jats:italic>pfmdt<\/jats:italic>\n            gene (\n            <jats:italic>P<\/jats:italic>\n            = 0.87) or the number of PfTetQ KYNNNN repeats (\n            <jats:italic>P<\/jats:italic>\n            = 0.72).\n          <\/jats:p>","DOI":"10.1128\/aac.00345-15","type":"journal-article","created":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T19:10:15Z","timestamp":1433963415000},"page":"5080-5083","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["Molecular Markers and\n            <i>In Vitro<\/i>\n            Susceptibility to Doxycycline in Plasmodium falciparum Isolates from Thailand"],"prefix":"10.1128","volume":"59","author":[{"given":"Tiphaine","family":"Gaillard","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Parasitologie, D\u00e9partement d'Infectiologie de Terrain, Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, Marseille, France"},{"name":"Aix Marseille Universit\u00e9, Unit\u00e9 de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM 63, CNRS 7278, IRD 198, Inserm 1095, Marseille, France"},{"name":"F\u00e9d\u00e9ration des Laboratoires, H\u00f4pital d'Instruction des Arm\u00e9es Saint Anne, Toulon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanlaya","family":"Sriprawat","sequence":"additional","affiliation":[{"name":"Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Briolant","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Parasitologie, D\u00e9partement d'Infectiologie de Terrain, Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, Marseille, France"},{"name":"Aix Marseille Universit\u00e9, Unit\u00e9 de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM 63, CNRS 7278, IRD 198, Inserm 1095, Marseille, France"},{"name":"Direction Inter-Arm\u00e9es du Service de Sant\u00e9, Cayenne, French Guiana"},{"name":"Laboratoire de Parasitologie, Institut Pasteur de la Guyane, Cayenne, French 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du Paludisme, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Nosten","sequence":"additional","affiliation":[{"name":"Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand"},{"name":"Centre for Tropical Medicine, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Pradines","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Parasitologie, D\u00e9partement d'Infectiologie de Terrain, Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, Marseille, France"},{"name":"Aix Marseille Universit\u00e9, Unit\u00e9 de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM 63, CNRS 7278, IRD 198, Inserm 1095, Marseille, France"},{"name":"Centre National de R\u00e9f\u00e9rence du Paludisme, Marseille, France"},{"name":"Unit\u00e9 de Parasitologie et d'Entomologie, D\u00e9partement des Maladies Infectieuses, Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, Br\u00e9tigny sur Orge, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","volume-title":"Guidelines for the treatment of malaria","author":"World Health Organization","year":"2011","unstructured":"World Health Organization. 2011. 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