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Twenty-five pharyngeal isolates carried variants associated with reduced \u03b2-lactam susceptibility. Penicillin and ampicillin susceptibility testing confirmed reduced susceptibility among PBP2x variant isolates relative to those with the wild-type sequence.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.00354-26","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T06:46:42Z","timestamp":1780037202000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Identification of\n                    <i>Streptococcus pyogenes<\/i>\n                    isolates with reduced beta-lactam susceptibility in a cohort of children with pharyngitis"],"prefix":"10.1128","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8525-7566","authenticated-orcid":true,"given":"Daniel B.","family":"Amusin","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02ets8c94","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine","place":["Chicago, USA"]},{"id":[{"id":"https:\/\/ror.org\/02ets8c94","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine","place":["Chicago, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4041-6775","authenticated-orcid":true,"given":"Lacy M.","family":"Simons","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02ets8c94","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine","place":["Chicago, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dulce S.","family":"Garcia","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02ets8c94","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine","place":["Chicago, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5271-8143","authenticated-orcid":true,"given":"Samuel W. 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In Kimberlin DW, Banerjee R, Barnett ED, Lynfield R, Sawyer MH (ed), Red book: 2024\u20132027 report of the committee on infectious diseases. 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