{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:53:23Z","timestamp":1793084003087,"version":"4.5.0"},"reference-count":39,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2025,11,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Current therapeutic options for fluconazole-resistant\n                      <jats:italic toggle=\"yes\">Candida parapsilosis<\/jats:italic>\n                      (FLZR-CP) bloodstream infections (BSI) are limited to echinocandins and liposomal amphotericin B (L-AmB). To the best of our knowledge, no real-world comparative effectiveness studies have assessed these agents. This study aimed to compare the effectiveness of echinocandins and L-AmB for the treatment of FLZR-CP BSI. This retrospective, observational study was conducted in two hospitals in Italy between January 2018 and December 2022. Eligible patients were adults (\u226518 years old) with microbiologically confirmed FLZR-CP BSI who received targeted therapy with either echinocandins or L-AmB. Patients were matched (2:1) based on age, Charlson comorbidity index, presence of sepsis or septic shock, time to appropriate antifungal therapy (\u226448 hours or &gt; 48 hours from diagnosis), and infection source. A total of 63 patients were included (42 in the echinocandin group and 21 in the L-AmB group). In Cox regression, targeted therapy with echinocandins was not associated with increased mortality (adjusted hazard ratio 1.40; 95% confidence interval [CI] 0.33\u20135.92,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.645). An exploratory sensitivity analysis including patients who did not receive source control yielded consistent results (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.491). Furthermore, in the multivariable regression analysis, echinocandin therapy was not associated with an increased risk of persistent fungemia (adjusted odds ratio 1.61: 95% CI 0.43\u20135.99,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.476). Treatment with echinocandins and L-AmB resulted in similar 30-day mortality and persistent fungemia rates in patients with FLZR-CP BSI. These findings confirm that echinocandins are a viable treatment option for\n                      <jats:italic toggle=\"yes\">C. parapsilosis<\/jats:italic>\n                      BSI, even for patients with fluconazole-resistant strains.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.00355-25","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T12:07:41Z","timestamp":1759234061000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Comparative effectiveness of echinocandins and liposomal amphotericin B for fluconazole-resistant\n                    <i>Candida parapsilosis<\/i>\n                    bloodstream infections"],"prefix":"10.1128","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0697-3992","authenticated-orcid":false,"given":"Antonio","family":"Vena","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit, Policlinico San Martino Hospital \u2013 IRCCS","place":["Genoa, Italy"]},{"id":[{"id":"https:\/\/ror.org\/0107c5v14","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Health Sciences (DISSAL), University of Genoa","place":["Genoa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1940-5620","authenticated-orcid":false,"given":"Claudia","family":"Bartalucci","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Policlinico San Martino Hospital \u2013 IRCCS","place":["Genoa, Italy"]},{"id":[{"id":"https:\/\/ror.org\/0107c5v14","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Health Sciences (DISSAL), University of Genoa","place":["Genoa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Muccio","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Policlinico San Martino Hospital \u2013 IRCCS","place":["Genoa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3884-4933","authenticated-orcid":true,"given":"Giusy","family":"Tiseo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05xrcj819","id-type":"ROR","asserted-by":"publisher"}],"name":"Infectious Diseases Unit, Department of Clinical and Experimental Medicine, Azienda Ospedaliero Universitaria Pisana","place":["Pisa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5706-5583","authenticated-orcid":true,"given":"Patricia","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0111es613","id-type":"ROR","asserted-by":"publisher"}],"name":"Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Mara\u00f1\u00f3n","place":["Madrid, Spain"]},{"id":[{"id":"https:\/\/ror.org\/014v12a39","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital Gregorio Mara\u00f1\u00f3n","place":["Madrid, Spain"]},{"name":"CIBER Enfermedades Respiratorias-CIBERES (CB06\/06\/0058)","place":["Madrid, Spain"]},{"id":[{"id":"https:\/\/ror.org\/02p0gd045","id-type":"ROR","asserted-by":"publisher"}],"name":"Medicine Department, School of Medicine, Universidad Complutense de Madrid","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Cesaretti","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05xrcj819","id-type":"ROR","asserted-by":"publisher"}],"name":"Infectious Diseases Unit, Department of Clinical and Experimental Medicine, Azienda Ospedaliero Universitaria Pisana","place":["Pisa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5863-5805","authenticated-orcid":true,"given":"Vincenzo","family":"Di Pilato","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0107c5v14","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa","place":["Genoa, Italy"]},{"name":"Microbiology Unit, IRCCS Ospedale Policlinico San Martino","place":["Genoa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Marchese","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0107c5v14","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa","place":["Genoa, Italy"]},{"name":"Microbiology Unit, IRCCS Ospedale Policlinico San Martino","place":["Genoa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramona","family":"Barbieri","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0107c5v14","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa","place":["Genoa, Italy"]},{"name":"Microbiology Unit, IRCCS Ospedale Policlinico San Martino","place":["Genoa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Forniti","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05xrcj819","id-type":"ROR","asserted-by":"publisher"}],"name":"Infectious Diseases Unit, Department of Clinical and Experimental Medicine, Azienda Ospedaliero Universitaria Pisana","place":["Pisa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2385-1759","authenticated-orcid":true,"given":"Daniele Roberto","family":"Giacobbe","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Policlinico San Martino Hospital \u2013 IRCCS","place":["Genoa, Italy"]},{"id":[{"id":"https:\/\/ror.org\/0107c5v14","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Health Sciences (DISSAL), University of Genoa","place":["Genoa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Limongelli","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Policlinico San Martino Hospital \u2013 IRCCS","place":["Genoa, Italy"]},{"id":[{"id":"https:\/\/ror.org\/0107c5v14","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Health Sciences (DISSAL), University of Genoa","place":["Genoa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6975-8114","authenticated-orcid":true,"given":"Antonella","family":"Lupetti","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03ad39j10","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa","place":["Pisa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Mikulska","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Policlinico San Martino Hospital \u2013 IRCCS","place":["Genoa, Italy"]},{"id":[{"id":"https:\/\/ror.org\/0107c5v14","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Health Sciences (DISSAL), University of Genoa","place":["Genoa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6766-8297","authenticated-orcid":true,"given":"Jon","family":"Salmanton-Garc\u00eda","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00rcxh774","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital Cologne, University of Cologne","place":["Cologne, Germany"]},{"id":[{"id":"https:\/\/ror.org\/00rcxh774","id-type":"ROR","asserted-by":"publisher"}],"name":"Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), University of Cologne","place":["Cologne, Germany"]},{"id":[{"id":"https:\/\/ror.org\/00rcxh774","id-type":"ROR","asserted-by":"publisher"}],"name":"Department I of Internal Medicine, European Confederation for Medical Mycology (ECMM) Excellence Center, University of Cologne","place":["Cologne, Germany"]},{"name":"German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne","place":["Cologne, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7226-8212","authenticated-orcid":true,"given":"Ana","family":"Soriano Mart\u00edn","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0111es613","id-type":"ROR","asserted-by":"publisher"}],"name":"Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Mara\u00f1\u00f3n","place":["Madrid, Spain"]},{"id":[{"id":"https:\/\/ror.org\/014v12a39","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital Gregorio Mara\u00f1\u00f3n","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Taramasso","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Policlinico San Martino Hospital \u2013 IRCCS","place":["Genoa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maricela","family":"Valerio","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0111es613","id-type":"ROR","asserted-by":"publisher"}],"name":"Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Mara\u00f1\u00f3n","place":["Madrid, Spain"]},{"id":[{"id":"https:\/\/ror.org\/014v12a39","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital Gregorio Mara\u00f1\u00f3n","place":["Madrid, Spain"]},{"name":"CIBER Enfermedades Respiratorias-CIBERES (CB06\/06\/0058)","place":["Madrid, Spain"]},{"id":[{"id":"https:\/\/ror.org\/02p0gd045","id-type":"ROR","asserted-by":"publisher"}],"name":"Medicine Department, School of Medicine, Universidad Complutense de Madrid","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6254-4570","authenticated-orcid":true,"given":"Pilar","family":"Escribano","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0111es613","id-type":"ROR","asserted-by":"publisher"}],"name":"Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Mara\u00f1\u00f3n","place":["Madrid, Spain"]},{"id":[{"id":"https:\/\/ror.org\/014v12a39","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital Gregorio Mara\u00f1\u00f3n","place":["Madrid, Spain"]},{"name":"CIBER Enfermedades Respiratorias-CIBERES (CB06\/06\/0058)","place":["Madrid, Spain"]},{"id":[{"id":"https:\/\/ror.org\/03f6h9044","id-type":"ROR","asserted-by":"publisher"}],"name":"Faculty of Health Sciences - HM Hospitals, Universidad Camilo Jos\u00e9 Cela","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7901-8355","authenticated-orcid":true,"given":"Jesus","family":"Guinea","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0111es613","id-type":"ROR","asserted-by":"publisher"}],"name":"Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Mara\u00f1\u00f3n","place":["Madrid, Spain"]},{"id":[{"id":"https:\/\/ror.org\/014v12a39","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital Gregorio Mara\u00f1\u00f3n","place":["Madrid, Spain"]},{"name":"CIBER Enfermedades Respiratorias-CIBERES (CB06\/06\/0058)","place":["Madrid, Spain"]},{"id":[{"id":"https:\/\/ror.org\/03f6h9044","id-type":"ROR","asserted-by":"publisher"}],"name":"Faculty of Health Sciences - HM Hospitals, Universidad Camilo Jos\u00e9 Cela","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Bouza","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0111es613","id-type":"ROR","asserted-by":"publisher"}],"name":"Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Mara\u00f1\u00f3n","place":["Madrid, Spain"]},{"id":[{"id":"https:\/\/ror.org\/014v12a39","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital Gregorio Mara\u00f1\u00f3n","place":["Madrid, Spain"]},{"name":"CIBER Enfermedades Respiratorias-CIBERES (CB06\/06\/0058)","place":["Madrid, Spain"]},{"id":[{"id":"https:\/\/ror.org\/02p0gd045","id-type":"ROR","asserted-by":"publisher"}],"name":"Medicine Department, School of Medicine, Universidad Complutense de Madrid","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3813-8796","authenticated-orcid":true,"given":"Marco","family":"Falcone","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05xrcj819","id-type":"ROR","asserted-by":"publisher"}],"name":"Infectious Diseases Unit, Department of Clinical and Experimental Medicine, Azienda Ospedaliero Universitaria Pisana","place":["Pisa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Bassetti","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Policlinico San Martino Hospital \u2013 IRCCS","place":["Genoa, Italy"]},{"id":[{"id":"https:\/\/ror.org\/0107c5v14","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Health Sciences (DISSAL), University of Genoa","place":["Genoa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"On behalf of ESCMID Fungal Infection Study Group (EFISG)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(23)00067-8"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/ffunb.2022.1010782"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciae603"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13050"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02997"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ933"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(21)00203-6"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(24)00749-7"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ791"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00262-08"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00046-13"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2022.2153086"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2021.03.003"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3181e9441b"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.3.2.167"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkac351"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1214\/09-STS313"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac656"},{"key":"e_1_3_4_21_2","unstructured":"Yuan YC. 2010. Multiple imputation for missing data: concepts and new development (Version 9.0). Available from: https:\/\/facweb.cdm.depaul.edu\/sjost\/csc423\/ documents\/multipleimputation.pdf. Retrieved 14 Feb 2025."},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/0962280220921889"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00872-6"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021585"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa066906"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60605-9"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-003-0973-8"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1086\/520980"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu158"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw305"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.30.12.1207"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13070"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof9020277"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof7040259"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67490-9"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00911-09"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-019-03477-3"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-020-00281-x"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183485"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.10.023"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00355-25","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00355-25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:06:50Z","timestamp":1785884810000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.00355-25"}},"subtitle":[],"editor":[{"given":"Andreas H.","family":"Groll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,11,5]]},"references-count":39,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11,5]]}},"alternative-id":["10.1128\/aac.00355-25"],"URL":"https:\/\/doi.org\/10.1128\/aac.00355-25","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,5]]},"assertion":[{"value":"2025-03-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00355-25"}}