{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T14:18:46Z","timestamp":1773843526467,"version":"3.50.1"},"reference-count":22,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Daptomycin has in vitro activity against gram-positive anaerobic bacteria, although limited numbers of species have been tested. We studied the in vitro activities of daptomycin, vancomycin, and penicillin against more than 100 strains each of\n            <jats:italic>Clostridium difficile<\/jats:italic>\n            ,\n            <jats:italic>C. perfringens<\/jats:italic>\n            ,\n            <jats:italic>Finegoldia magna<\/jats:italic>\n            , and\n            <jats:italic>Propionibacterium acnes<\/jats:italic>\n            . Daptomycin Etest MICs and results from time-kill studies were determined for selected strains. For 392 of 421 strains (93%), daptomycin was inhibitory at \u22641 \u03bcg\/ml, including 15 of 16 strains of\n            <jats:italic>C. difficile<\/jats:italic>\n            with elevated linezolid MICs of 8 and 16 \u03bcg\/ml, all 32 strains with moxifloxacin MICs of \u22654 \u03bcg\/ml, and all 16 strains resistant to clindamycin. Daptomycin MICs were also \u22641 \u03bcg\/ml for all 16\n            <jats:italic>F. magna<\/jats:italic>\n            strains resistant to clindamycin and all 32 strains resistant to tetracycline. Only one strain, a\n            <jats:italic>C. perfringens<\/jats:italic>\n            strain, had a MIC of &gt;2 \u03bcg\/ml to daptomycin. Eighty-five and 92.5% of the Etest MICs were within 1 dilution of the agar dilution method for all drugs at 24 and 48 h, respectively. In time-kill studies, a\n            <jats:italic>C. difficile<\/jats:italic>\n            strain was inhibited by both daptomycin and vancomycin at 1, 2, 4, 8, and 24 h; colony counts were decreased by 2.3 to 2.9 log at 24 h. Vancomycin was not bactericidal for\n            <jats:italic>C. perfringens<\/jats:italic>\n            ; however, daptomycin showed bactericidal activity as early as 1 h at four and eight times the MIC and at 2 and 4 h at two and four times the MIC.\n          <\/jats:p>","DOI":"10.1128\/aac.00357-06","type":"journal-article","created":{"date-parts":[[2006,7,26]],"date-time":"2006-07-26T18:17:58Z","timestamp":1153937878000},"page":"2728-2731","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":46,"title":["In Vitro Activities of Daptomycin, Vancomycin, and Penicillin against\n            <i>Clostridium difficile<\/i>\n            ,\n            <i>C. perfringens<\/i>\n            ,\n            <i>Finegoldia magna<\/i>\n            , and\n            <i>Propionibacterium acnes<\/i>"],"prefix":"10.1128","volume":"50","author":[{"given":"Kerin L.","family":"Tyrrell","sequence":"first","affiliation":[{"name":"R. M. Alden Research Lab, Santa Monica, California 90404"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane M.","family":"Citron","sequence":"additional","affiliation":[{"name":"R. M. Alden Research Lab, Santa Monica, California 90404"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumi A.","family":"Warren","sequence":"additional","affiliation":[{"name":"R. M. Alden Research Lab, Santa Monica, California 90404"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen T.","family":"Fernandez","sequence":"additional","affiliation":[{"name":"R. M. Alden Research Lab, Santa Monica, California 90404"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Vreni","family":"Merriam","sequence":"additional","affiliation":[{"name":"R. M. Alden Research Lab, Santa Monica, California 90404"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellie J. C.","family":"Goldstein","sequence":"additional","affiliation":[{"name":"R. M. Alden Research Lab, Santa Monica, California 90404"},{"name":"UCLA School of Medicine, Los Angeles, California 90095"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.11.3561-3566.2003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/420818"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.6.1919-1922.2001"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.32.5.788"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.7.2334-2338.2003"},{"key":"e_1_3_2_7_2","unstructured":"Clinical and Laboratory Standards Institute\/NCCLS. 2006. Performance standards for antimicrobial susceptibility testing; 16th informational supplement. Clinical and Laboratory Standards Institute Wayne Pa."},{"key":"e_1_3_2_8_2","unstructured":"Clinical and Laboratory Standards Institute\/NCCLS. 2004. Methods for antimicrobial susceptibility testing of anaerobic bacteria. Approved standard M11-A6. NCCLS Wayne Pa."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/49.3.467"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.1.337-341.2003"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.1.408-413.2005"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02013071"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.35.9.1710"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.10.5285-5287.2005"},{"key":"e_1_3_2_15_2","unstructured":"Jousimies-Somer H. R. P. Summanen D. M. Citron E. J. Baron H. M. Wexler and S. M. Finegold. 2002. Wadsworth-KTL anaerobic bacteriology manual. Star Publishing Belmont Calif."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1086\/428616"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.2.595-597.2006"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.8.3513-3516.2005"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2004.07.002"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.6.1799-1802.2001"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.2.655-656.2006"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1086\/431671"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/48.4.563"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00357-06","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00357-06","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T19:13:50Z","timestamp":1645470830000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00357-06"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1128\/AAC.00357-06"],"URL":"https:\/\/doi.org\/10.1128\/aac.00357-06","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8]]},"assertion":[{"value":"2006-03-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-05-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}