{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T17:43:01Z","timestamp":1781890981842,"version":"3.54.5"},"reference-count":22,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Five GES-producing\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Enterobacteriaceae<\/jats:named-content>\n            isolates that displayed an extended-spectrum \u03b2-lactamase (ESBL) phenotype harbored two GES variants: GES-7 ESBL and GES-6 carbapenemase. In all isolates, the two GES alleles were located on the same integron that was inserted into an 80-kb IncM1 self-conjugative plasmid. Whole-genome sequencing suggested\n            <jats:italic>in vivo<\/jats:italic>\n            horizontal gene transfer of the plasmid along with clonal diffusion of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Enterobacter cloacae<\/jats:named-content>\n            . To our knowledge, this is the first description in Europe of clustered\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Enterobacteriaceae<\/jats:named-content>\n            isolates carrying two GES \u03b2-lactamases, of which one has extended activity toward carbapenems.\n          <\/jats:p>","DOI":"10.1128\/aac.00360-16","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T16:26:28Z","timestamp":1464107188000},"page":"5040-5043","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":23,"title":["Spread of Plasmids Carrying Multiple GES Variants"],"prefix":"10.1128","volume":"60","author":[{"given":"Gaelle","family":"Cuzon","sequence":"first","affiliation":[{"name":"Bact\u00e9riologie-Hygiene Unit, APHP, Bic\u00eatre Hospital, Le Kremlin-Bic\u00eatre, France"},{"name":"Universit\u00e9 Paris Sud, Universit\u00e9 Paris Saclay, LabEx Lermit, Faculty of Medicine, Le Kremlin-Bicetre, France"},{"name":"French National Reference Center for Antibiotic Resistance: Carbapenemase-Producing Enterobacteriaceae, Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Bogaerts","sequence":"additional","affiliation":[{"name":"Belgian National Reference Centre for Monitoring of Antimicrobial Resistance in Gram-Negative Bacteria, CHU Dinant-Godinne UCL Namur, Universit\u00e9 Catholique de Louvain, Yvoir, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Bauraing","sequence":"additional","affiliation":[{"name":"Belgian National Reference Centre for Monitoring of Antimicrobial Resistance in Gram-Negative Bacteria, CHU Dinant-Godinne UCL Namur, Universit\u00e9 Catholique de Louvain, Yvoir, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Te-Din","family":"Huang","sequence":"additional","affiliation":[{"name":"Belgian National Reference Centre for Monitoring of Antimicrobial Resistance in Gram-Negative Bacteria, CHU Dinant-Godinne UCL Namur, Universit\u00e9 Catholique de Louvain, Yvoir, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2307-3232","authenticated-orcid":false,"given":"R\u00e9my A.","family":"Bonnin","sequence":"additional","affiliation":[{"name":"Bact\u00e9riologie-Hygiene Unit, APHP, Bic\u00eatre Hospital, Le Kremlin-Bic\u00eatre, France"},{"name":"Universit\u00e9 Paris Sud, Universit\u00e9 Paris Saclay, LabEx Lermit, Faculty of Medicine, Le Kremlin-Bicetre, France"},{"name":"French National Reference Center for Antibiotic Resistance: Carbapenemase-Producing Enterobacteriaceae, Le Kremlin-Bic\u00eatre, France"},{"name":"Evolution and Ecology of Resistance to Antibiotics (EERA) Unit, Institut Pasteur-APHP-Universit\u00e9 Paris Sud, Le Kremlin-Bicetre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youri","family":"Glupczynski","sequence":"additional","affiliation":[{"name":"Belgian National Reference Centre for Monitoring of Antimicrobial Resistance in Gram-Negative Bacteria, CHU Dinant-Godinne UCL Namur, Universit\u00e9 Catholique de Louvain, Yvoir, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Naas","sequence":"additional","affiliation":[{"name":"Bact\u00e9riologie-Hygiene Unit, APHP, Bic\u00eatre Hospital, Le Kremlin-Bic\u00eatre, France"},{"name":"Universit\u00e9 Paris Sud, Universit\u00e9 Paris Saclay, LabEx Lermit, Faculty of Medicine, Le Kremlin-Bicetre, France"},{"name":"French National Reference Center for Antibiotic Resistance: Carbapenemase-Producing Enterobacteriaceae, Le Kremlin-Bic\u00eatre, France"},{"name":"Evolution and Ecology of Resistance to Antibiotics (EERA) Unit, Institut Pasteur-APHP-Universit\u00e9 Paris Sud, Le Kremlin-Bicetre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.3.622-632.2000"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1710.110655"},{"key":"e_1_3_1_4_2","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.2174\/1389450117666160310144501","article-title":"Structural and functional aspects of class A carbapenemases","volume":"17","author":"Naas T","year":"2016","unstructured":"Naas T, Dortet L, Iorga BI. 2016. Structural and functional aspects of class A carbapenemases. Curr Drug Targets 17:1006\u20131028.","journal-title":"Curr Drug Targets"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.9.2598-2603.2001"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01861.x"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1609.091389"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0147-619X(84)90063-5"},{"key":"e_1_3_1_9_2","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.01340-15","article-title":"Draft genome sequence of the Serratia rubidaea CIP 103234T reference strain, a human-opportunistic pathogen","volume":"3","author":"Bonnin RA","year":"2015","unstructured":"Bonnin RA, Girlich D, Imanci D, Dortet L, Naas T. 2015. Draft genome sequence of the Serratia rubidaea CIP 103234T reference strain, a human-opportunistic pathogen. 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