{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:05:13Z","timestamp":1791093913233,"version":"4.1.0"},"reference-count":39,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Alpha-galactosyl ceramide (\u03b1-GalCer) has been known to bind to the CD1d receptor on dendritic cells and activate invariant natural killer T (iNKT) cells, which subsequently secrete T-helper-cell 1 (Th1) and Th2 cytokines, which correlate with anti-infection activity and the prevention of autoimmune diseases, respectively. \u03b1-GalCer elicits the secretion of these two cytokines nonselectively, and thus, its effectiveness is limited by the opposing effects of the Th1 and Th2 cytokines. Reported here is the synthesis of a new \u03b1-GalCer analog (compound C34), based on the structure of CD1d, with a 4-(4-fluorophenoxy) phenyl undecanoyl modification of the\n            <jats:italic>N<\/jats:italic>\n            -acyl moiety of \u03b1-GalCer. Using several murine bacterial and viral infection models, we demonstrated that C34 has superior antibacterial and antiviral activities in comparison with those of several other Th1-selective glycolipids and that it is most effective by administering it to mice in a prophylactic manner before or shortly after infection.\n          <\/jats:p>","DOI":"10.1128\/aac.00368-10","type":"journal-article","created":{"date-parts":[[2010,7,27]],"date-time":"2010-07-27T00:51:41Z","timestamp":1280191901000},"page":"4129-4136","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":34,"title":["<i>In Vivo<\/i>\n            Protection Provided by a Synthetic New Alpha-Galactosyl Ceramide Analog against Bacterial and Viral Infections in Murine Models"],"prefix":"10.1128","volume":"54","author":[{"given":"Kun-Hsien","family":"Lin","sequence":"first","affiliation":[{"name":"Genomics Research Center"},{"name":"Department of Chemistry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Jong","family":"Liang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-I","family":"Huang","sequence":"additional","affiliation":[{"name":"Genomics Research Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Ying","family":"Lin-Chu","sequence":"additional","affiliation":[{"name":"Genomics Research Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Yao","family":"Su","sequence":"additional","affiliation":[{"name":"Genomics Research Center"},{"name":"Institute of Biochemical Sciences, National Taiwan University, Taipei 106, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ling","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Tsong","family":"Jan","sequence":"additional","affiliation":[{"name":"Genomics Research Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ling","family":"Lin","sequence":"additional","affiliation":[{"name":"Genomics Research Center"},{"name":"Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yih-Shyun E.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Genomics Research Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Huey","family":"Wong","sequence":"additional","affiliation":[{"name":"Genomics Research Center"},{"name":"Department of Chemistry"},{"name":"Institute of Biochemical Sciences, National Taiwan University, Taipei 106, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.10.086"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.6.3625"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0703824104"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1996.0457"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.11489"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2004.12.027"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar050006z"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja062740z"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1309"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011889"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200738017"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2007.03.006"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.9.4294-4303.2002"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22714"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.7.921"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03407"},{"key":"e_1_3_2_18_2","first-page":"529","volume":"7","year":"1995","unstructured":"Kobayashi, E., K. 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