{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:19:26Z","timestamp":1788848366616,"version":"build-2803163510"},"reference-count":53,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Antibiotic-resistant microbes, such as methicillin-resistant<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Staphylococcus aureus<\/jats:named-content>, seriously threaten human health. The outbreak of \u201csuperbugs\u201d in recent years emphasizes once again the need for the development of new antimicrobial agents or resources. Antimicrobial peptides have an evident bactericidal effect against multidrug-resistant pathogens. In the present study, a new antimicrobial peptide, ctriporin, was cloned and characterized from the venom of the scorpion<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Chaerilus tricostatus<\/jats:named-content>, an animal which has not yet been explored for toxic peptide resources. The MICs of ctriporin against<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Staphylococcus aureus<\/jats:named-content>,<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Bacillus thuringiensis<\/jats:named-content>,<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Bacillus subtilis<\/jats:named-content>,<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Micrococcus luteus<\/jats:named-content>, and<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Candida albicans<\/jats:named-content>are 5 to 20 \u03bcg\/ml. Meanwhile, it MIC against clinical antibiotic-resistant bacterial strains is 10 \u03bcg\/ml. Furthermore, the potential for ctriporin to be used as a topical antibiotic for treating staphylococcal skin infections was investigated. External use of the peptide ctriporin dramatically decreased the bacterial counts and cured skin infections in mice. In addition, ctriporin demonstrates antimicrobial efficacy via the bactericidal mechanism of rapid cell lysis. Together, these results suggest the potential of developing ctriporin as a new topical antibiotic.<\/jats:p>","DOI":"10.1128\/aac.00369-11","type":"journal-article","created":{"date-parts":[[2011,8,30]],"date-time":"2011-08-30T01:47:57Z","timestamp":1314668877000},"page":"5220-5229","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":59,"title":["Ctriporin, a New Anti-Methicillin-Resistant Staphylococcus aureus Peptide from the Venom of the Scorpion Chaerilus tricostatus"],"prefix":"10.1128","volume":"55","author":[{"given":"Zheng","family":"Fan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyang","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Di","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingliang","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2003.01278.x"},{"key":"e_1_3_2_3_2","first-page":"16","article-title":"The emergence of vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus. Clin. Microbiol","volume":"12","author":"Appelbaum P. C","year":"2006","unstructured":"AppelbaumP. C. 2006. The emergence of vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus. Clin. Microbiol. Infect. 12(Suppl. 1):16\u201323.","journal-title":"Infect."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2007.07.011"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/502221"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)68351-1"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(91)90044-V"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.10.6771-6781.2005"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.1778"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.SMJ.0000163302.72469.28"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.1.297"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01384-3"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3590035"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00542-08"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5472"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20887"},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.3201\/eid1411.080381","article-title":"Molecular epidemiology of methicillin-resistant Staphylococcus aureus, rural southwestern Alaska. Emerg","volume":"14","author":"David M. Z.","year":"2008","unstructured":"DavidM. Z. RudolphK. M. HennessyT. W. Boyle-VavraS. DaumR. S.. 2008. Molecular epidemiology of methicillin-resistant Staphylococcus aureus, rural southwestern Alaska. Emerg. Infect. Dis. 14:1693\u20131699.","journal-title":"Infect. Dis."},{"key":"e_1_3_2_18_2","first-page":"222","article-title":"The molecular evolution of methicillin-resistant Staphylococcus aureus. Clin. Microbiol","volume":"13","author":"Deurenberg R. H.","year":"2007","unstructured":"DeurenbergR. H.. 2007. The molecular evolution of methicillin-resistant Staphylococcus aureus. Clin. Microbiol. Infect. 13:222\u2013235.","journal-title":"Infect."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.2174\/138161209788682325"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.53.070184.003313"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.47.29537"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.122108599"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro908"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn074"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.5.1213"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.10.1201"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1267"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3300061"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00056-05"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.2807\/ese.15.41.19688-en"},{"key":"e_1_3_2_31_2","first-page":"30","article-title":"Severe vancomycin-induced anaphylactic reaction","volume":"46","author":"Kupstaite R.","year":"2010","unstructured":"KupstaiteR.. 2010. Severe vancomycin-induced anaphylactic reaction. Medicina (Kaunas) 46:30\u201333.","journal-title":"Medicina (Kaunas)"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701235"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2005.06.008"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0255-0857(21)02524-X"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.58.2.128"},{"key":"e_1_3_2_36_2","first-page":"1142","article-title":"Chemical nature of toxic protein of venom of the South Indian scorpion Heterometrus scaber","volume":"18","author":"Nair R. B","year":"1980","unstructured":"NairR. B. 1980. Chemical nature of toxic protein of venom of the South Indian scorpion Heterometrus scaber. Indian J. Exp. Biol. 18:1142\u20131144.","journal-title":"Indian J. Exp. Biol."},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00613-08"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021481"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-4179(00)00052-8"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.011122-0"},{"key":"e_1_3_2_41_2","first-page":"1","article-title":"Novel alternatives to antibiotics: bacteriophages, bacterial cell wall hydrolases, and antimicrobial peptides","volume":"104","author":"Parisien A.","year":"2008","unstructured":"ParisienA. AllainB. ZhangJ. MandevilleR. LanC. Q.. 2008. Novel alternatives to antibiotics: bacteriophages, bacterial cell wall hydrolases, and antimicrobial peptides. J. Appl. Microbiol. 104:1\u201313.","journal-title":"J. Appl. Microbiol."},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1155\/MI\/2006\/54273"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2007.06.001"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1006\/frne.1995.1012"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.8.3112-3118.2004"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1466252308001497"},{"key":"e_1_3_2_47_2","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3201\/eid1605.090851","article-title":"Methicillin-resistant Staphylococcus aureus carriage and risk factors for skin infections, Southwestern Alaska, U.S.A. Emerg","volume":"16","author":"Stevens A. M.","year":"2010","unstructured":"StevensA. M.. 2010. Methicillin-resistant Staphylococcus aureus carriage and risk factors for skin infections, Southwestern Alaska, U.S.A. Emerg. Infect. Dis. 16:797\u2013803.","journal-title":"Infect. Dis."},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2000.01556.x"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.4103\/0974-777X.59251"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh025"},{"key":"e_1_3_2_51_2","first-page":"11","article-title":"Antimicrobial peptides in human skin disease","volume":"18","author":"Yamasaki K.","year":"2008","unstructured":"YamasakiK. GalloR. L.. 2008. Antimicrobial peptides in human skin disease. Eur. J. Dermatol. 18:11\u201321.","journal-title":"Eur. J. Dermatol."},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2009.10.008"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.249.4973.1176"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01436-08"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00369-11","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00369-11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,9]],"date-time":"2025-03-09T11:39:12Z","timestamp":1741520352000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00369-11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":53,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1128\/AAC.00369-11"],"URL":"https:\/\/doi.org\/10.1128\/aac.00369-11","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11]]},"assertion":[{"value":"2011-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-07-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-10-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}