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Given the poor outcome of severe MRSA infections and limitations of the current approved treatments, there is growing interest in repurposing \u03b2-lactams as part of a treatment strategy for these infections. Here, we review the current literature on \u03b2-lactam susceptibility phenotypes in MRSA. We describe four phenotypes: oxacillin-susceptible, sensitivity to combinations of \u03b2-lactam-\u03b2-lactamase inhibitors, NaHCO\n                      <jats:sub>3<\/jats:sub>\n                      responsiveness, and synergy between classes of \u03b2-lactams that target different penicillin-binding proteins. For each phenotype, we discuss the genetic background, known explanatory biological mechanisms, and associations between MRSA \u03b2-lactam susceptibility phenotype and treatment response to \u03b2-lactam therapy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.00374-26","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T14:57:09Z","timestamp":1783349829000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["An Achilles' heel for methicillin-resistant\n                    <i>Staphylococcus aureus<\/i>\n                    ? 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