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PER-14 differs from PER-2 by an S130T substitution. Through combined functional and\n                      <jats:italic toggle=\"yes\">in silico<\/jats:italic>\n                      analyses, we demonstrated that PER-14 is resistant to avibactam and relebactam inhibition while retaining an extended-spectrum activity and the ability to hydrolyze cefiderocol, as the S130T substitution affects the proper binding of the DBOs.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.00378-26","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T14:48:12Z","timestamp":1784645292000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["PER-14, a \u03b2-lactamase variant with reduced sensitivity to avibactam and 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