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Bronchocavitary\n            <jats:italic>Mycobacterium abscessus<\/jats:italic>\n            disease is associated with poor treatment outcomes. In caseum surrogate,\n            <jats:italic>M. abscessus<\/jats:italic>\n            entered an extended stationary phase showing tolerance to killing by most current antibiotics, suggesting that caseum persisters contribute to the poor performance of available treatments. Novel ADP-ribosylation-resistant rifabutin analogs exhibited bactericidal activity against these\n            <jats:italic>M. abscessus<\/jats:italic>\n            persisters at concentrations achievable by rifamycins in caseum.\n          <\/jats:p>","DOI":"10.1128\/aac.00381-23","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T13:00:19Z","timestamp":1690376419000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["ADP-ribosylation-resistant rifabutin analogs show improved bactericidal activity against drug-tolerant\n            <i>M. abscessus<\/i>\n            in caseum surrogate"],"prefix":"10.1128","volume":"67","author":[{"given":"Min","family":"Xie","sequence":"first","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health , Nutley, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uday S.","family":"Ganapathy","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health , Nutley, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota , Minneapolis, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Osiecki","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health , Nutley, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jansy P.","family":"Sarathy","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health , Nutley, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Dartois","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health , Nutley, New Jersey, USA"},{"name":"Department of Medical Sciences, Hackensack Meridian School of Medicine , Nutley, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney C.","family":"Aldrich","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota , Minneapolis, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9604-9452","authenticated-orcid":true,"given":"Thomas","family":"Dick","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health , Nutley, New Jersey, USA"},{"name":"Department of Medical Sciences, Hackensack Meridian School of Medicine , Nutley, New Jersey, USA"},{"name":"Department of Microbiology and Immunology, Georgetown University , Washington, District of Columbia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.07.035"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00978-21"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw466"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02215-20"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20220445"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00159-19"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02266-17"},{"key":"e_1_3_3_9_2","first-page":"S231","article-title":"Studies on the treatment of tuberculosis undertaken by the British Medical Research Council tuberculosis units, 1946-1986, with relevant subsequent publications","volume":"3","author":"Fox W","year":"1999","unstructured":"Fox W , Ellard GA , Mitchison DA . 1999. Studies on the treatment of tuberculosis undertaken by the British Medical Research Council tuberculosis units, 1946-1986, with relevant subsequent publications. 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