{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:24:16Z","timestamp":1791933856925,"version":"4.3.4"},"reference-count":49,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2013,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n A population-based survey was conducted to investigate the epidemiology of and antifungal resistance in Spanish clinical strains of filamentous fungi isolated from deep tissue samples, blood cultures, and respiratory samples. The study was conducted in two different periods (October 2010 and May 2011) to analyze seasonal variations. A total of 325 strains were isolated in 29 different hospitals. The average prevalence was 0.0016\/1,000 inhabitants. Strains were identified by sequencing of DNA targets and susceptibility testing by the European Committee for Antimicrobial Susceptibility Testing reference procedure. The most frequently isolated genus was\n Aspergillus<\/jats:named-content>\n , accounting for 86.3% of the isolates, followed by\n Scedosporium<\/jats:named-content>\n at 4.7%; the order Mucorales at 2.5%;\n Penicillium<\/jats:named-content>\n at 2.2%, and\n Fusarium<\/jats:named-content>\n at 1.2%. The most frequent species was\n Aspergillus fumigatus<\/jats:named-content>\n (48.5%), followed by\n A. flavus<\/jats:named-content>\n (8.4%),\n A. terreus<\/jats:named-content>\n (8.1%),\n A. tubingensis<\/jats:named-content>\n (6.8%), and\n A. niger<\/jats:named-content>\n (6.5%). Cryptic\/sibling\n Aspergillus<\/jats:named-content>\n species accounted for 12% of the cases. Resistance to amphotericin B was found in 10.8% of the isolates tested, while extended-spectrum triazole resistance ranged from 10 to 12.7%, depending on the azole tested. Antifungal resistance was more common among emerging species such as those of\n Scedosporium<\/jats:named-content>\n and Mucorales and also among cryptic species of\n Aspergillus<\/jats:named-content>\n , with 40% of these isolates showing resistance to all of the antifungal compounds tested. Cryptic\n Aspergillus<\/jats:named-content>\n species seem to be underestimated, and their correct classification could be clinically relevant. The performance of antifungal susceptibility testing of the strains implicated in deep infections and multicentric studies is recommended to evaluate the incidence of these cryptic species in other geographic areas.\n <\/jats:p>","DOI":"10.1128\/aac.00383-13","type":"journal-article","created":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T04:58:27Z","timestamp":1368507507000},"page":"3380-3387","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":241,"title":["Population-Based Survey of Filamentous Fungi and Antifungal Resistance in Spain (FILPOP Study)"],"prefix":"10.1128","volume":"57","author":[{"given":"A.","family":"Alastruey-Izquierdo","sequence":"first","affiliation":[{"name":"National Center for Microbiology, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Mellado","sequence":"additional","affiliation":[{"name":"National Center for Microbiology, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Pel\u00e1ez","sequence":"additional","affiliation":[{"name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Pem\u00e1n","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Fe, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Zapico","sequence":"additional","affiliation":[{"name":"Hospital Universitario Donostia, Guipuzcoa, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Central de Asturias, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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