{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:17:22Z","timestamp":1788369442835,"version":"build-2803163510"},"reference-count":32,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                      ST383 has emerged as a high-risk clone, characterized by carbapenem resistance and increasing detection of hypervirulence determinants. We describe a phylogenetically distinct ST383 sub-lineage in Lebanon, defined by the acquisition of ICEKp5, which carries the yersiniabactin locus. Three ST383\n                      <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                      clinical isolates (LBN_CAKp91, LBN_CTKp3, and LBN_CTKp11) recovered from a Lebanese medical center were subjected to whole-genome sequencing. Comparative genomic analysis included regional ST383 strains and previously characterized Lebanese isolates. The study isolates formed a tight, monophyletic cluster (three to nine single-nucleotide polymorphisms [SNPs]) that is phylogenetically distinct from the previously reported Lebanese ST383 clone (&gt;164 SNPs) and grouped most closely to an Egyptian ST383 strain (59\u201365 SNPs). All three isolates carried ICEKp5 with yersiniabactin lineage\n                      <jats:italic toggle=\"yes\">ybt14<\/jats:italic>\n                      , a feature absent in the earlier Lebanese ST383 clone. The isolates were the only ST383 strains to harbor the full spectrum of hypervirulence determinants to date, including capsule regulators (\n                      <jats:italic toggle=\"yes\">rmpA<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">rmpA2<\/jats:italic>\n                      ), aerobactin (\n                      <jats:italic toggle=\"yes\">iucABCD<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">iutA<\/jats:italic>\n                      ), yersiniabactin, and the hypervirulence biomarker\n                      <jats:italic toggle=\"yes\">peg-344<\/jats:italic>\n                      . All isolates carried dual carbapenemases (\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>OXA-48<\/jats:sub>\n                      and\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>NDM-5<\/jats:sub>\n                      ) in addition to\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>CTX-M-15<\/jats:sub>\n                      and\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>CTX-M-14b<\/jats:sub>\n                      . The genetic environments of\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>OXA-48<\/jats:sub>\n                      and\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>NDM-5<\/jats:sub>\n                      were highly conserved across geographically diverse ST383 isolates, indicating common plasmid origins. This study describes a phylogenetically distinct hypervirulent extensively drug-resistant (XDR) ST383\n                      <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                      sub-lineage in Lebanon. The acquisition of ICEKp5, combined with plasmid-borne hypervirulence and resistance determinants, reveals the concerning convergence of hypervirulence and XDR. Enhanced surveillance and infection control measures are urgently needed to monitor this emerging high-risk clone.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.00384-26","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:44:50Z","timestamp":1785937490000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Identification of a hypervirulent extensively drug-resistant ST383\n                    <i>Klebsiella pneumoniae<\/i>\n                    sub-lineage carrying ICEKp5 in Lebanon"],"prefix":"10.1128","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0396-6892","authenticated-orcid":true,"given":"Martine","family":"Abboud","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00hqkan37","id-type":"ROR","asserted-by":"publisher"}],"name":"Biological Sciences, Lebanese American University","place":["Byblos, 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