{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:19:16Z","timestamp":1785424756126,"version":"3.56.0"},"reference-count":40,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["114-2320-B-715-005"],"award-info":[{"award-number":["114-2320-B-715-005"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MacKay Medical University","award":["MMU-RD-114-1A-P002"],"award-info":[{"award-number":["MMU-RD-114-1A-P002"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Elizabethkingia<\/jats:italic>\n                      species are opportunistic gram-negative pathogens associated with nosocomial infections and limited therapeutic options. Longitudinal data characterizing antimicrobial resistance and molecular determinants in Taiwan remain scarce. A total of 191 non-duplicate\n                      <jats:italic toggle=\"yes\">Elizabethkingia<\/jats:italic>\n                      clinical isolates were collected at the National Taiwan University Hospital between 2016 and 2022. Species identification was confirmed by 16S rRNA sequencing.\n                      <jats:italic toggle=\"yes\">Elizabethkingia anophelis<\/jats:italic>\n                      predominated (81.7%), followed by\n                      <jats:italic toggle=\"yes\">E. meningoseptica<\/jats:italic>\n                      (9.9%) and\n                      <jats:italic toggle=\"yes\">E. miricola<\/jats:italic>\n                      (7.9%). No major clone was identified. Genes involved in sialic acid metabolism were detected as follows:\n                      <jats:italic toggle=\"yes\">glmS<\/jats:italic>\n                      in 93.2% (178\/191),\n                      <jats:italic toggle=\"yes\">glmM<\/jats:italic>\n                      in 97.4% (186\/191),\n                      <jats:italic toggle=\"yes\">nagB<\/jats:italic>\n                      in 98.4% (188\/191),\n                      <jats:italic toggle=\"yes\">neuC2<\/jats:italic>\n                      in 24.5% (46\/191), and\n                      <jats:italic toggle=\"yes\">neuC<\/jats:italic>\n                      in 2.1% (4\/191) of isolates. Antimicrobial susceptibility testing showed very high nonsusceptibility for most agents (\u226599.5%). Lower rates of nonsusceptibility were observed for levofloxacin (MIC\n                      <jats:sub>50<\/jats:sub>\n                      \/MIC\n                      <jats:sub>90<\/jats:sub>\n                      = 1\/&gt;8 \u00b5g\/mL; 68.6% susceptible), ciprofloxacin (2\/&gt;4 \u00b5g\/mL; 49.2%), tigecycline (4\/&gt;8 \u00b5g\/mL; 23.0%), and rifampin (&gt;8\/&gt;16 \u00b5g\/mL; 19.9%). Using the breakpoint for other non-Enterobacterales, minocycline was active against all isolates (100.0%, 191\/191); however, applying the\n                      <jats:italic toggle=\"yes\">S. maltophilia<\/jats:italic>\n                      criteria, 42 isolates (22.0%) were nonsusceptible to minocycline. Among tetracycline determinants,\n                      <jats:italic toggle=\"yes\">tet<\/jats:italic>\n                      (X) was detected in 22 isolates (11.5%) and\n                      <jats:italic toggle=\"yes\">tet<\/jats:italic>\n                      (K) in 2 isolates (1.0%). With the criteria of\n                      <jats:italic toggle=\"yes\">S. maltophilia<\/jats:italic>\n                      , 10\n                      <jats:italic toggle=\"yes\">tet<\/jats:italic>\n                      (X)-positive isolates (10\/22, 45.5%) showed non-susceptibility to minocycline, implying that\n                      <jats:italic toggle=\"yes\">tet<\/jats:italic>\n                      (X) may contribute to the elevated MIC of minocycline. Our surveillance revealed a rapid increase in resistance to fluoroquinolones and rifampin and the emergence of\n                      <jats:italic toggle=\"yes\">tet<\/jats:italic>\n                      (X)-mediated tetracycline resistance in\n                      <jats:italic toggle=\"yes\">Elizabethkingia<\/jats:italic>\n                      spp. These findings underscore the need for continued molecular monitoring and region-specific antimicrobial stewardship.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.00387-26","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T13:36:26Z","timestamp":1781271386000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Molecular epidemiology and emerging\n                    <i>tet<\/i>\n                    (X)-associated resistance of\n                    <i>Elizabethkingia<\/i>\n                    spp. in Taiwan, 2016\u20132022"],"prefix":"10.1128","volume":"70","author":[{"given":"Yu-Tsung","family":"Huang","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05bqach95","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8782-3912","authenticated-orcid":true,"given":"Cheng-Yen","family":"Kao","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00se2k293","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Microbiology and Immunology, College of Life Science, National Yang Ming Chiao Tung University","place":["Taipei, 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