{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:20:32Z","timestamp":1790882432827,"version":"4.1.0"},"reference-count":37,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["UM1AI104681"],"award-info":[{"award-number":["UM1AI104681"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2026,6,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Novel \u03b2-lactam\/\u03b2-lactamase inhibitors (\u03b2L\/\u03b2LIs) are important therapies for carbapenem-resistant\n                      <jats:italic toggle=\"yes\">Pseudomonas aeruginosa<\/jats:italic>\n                      (CRPA). However, the global extent of resistance to these agents and the impact of resistance on patient outcomes are unclear. We therefore evaluated patients with CRPA isolates at 35 hospitals (nine countries) from December 2018 to November 2019. Antimicrobial susceptibility testing was performed at a central laboratory by agar dilution for ceftolozane-tazobactam (C\/T) and ceftazidime-avibactam (CZA) and by broth microdilution for imipenem-relebactam (I\/R). Characteristics and outcomes, including desirability of outcome rankings (DOOR), were compared between patients infected with isolates not susceptible vs susceptible to each agent. Of 800 CRPA isolates, susceptibility to C\/T, CZA, and I\/R was 69%, 67%, and 33%, respectively. USA isolates (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 526) were more frequently susceptible to these agents than isolates from other countries (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 274; C\/T: 83% vs 42%; CZA: 77% vs 47%; I\/R: 37% vs 23%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001 for each comparison) and isolates with carbapenemases (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 157) were less frequently susceptible than isolates without carbapenemases (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 643; C\/T: 7% vs 84%; CZA: 24% vs 77%; I\/R: 6% vs 39%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001 for each comparison). Thirty-day mortality and DOOR were similar overall in patients infected with isolates not susceptible vs susceptible to each \u03b2L\/\u03b2LI. However, the adjusted probability of a better DOOR outcome for a randomly selected patient with bacteremia due to a C\/T-not susceptible vs -susceptible isolate was 38.2% (95% confidence interval, 25.6%\u201352.7%). Resistance to novel \u03b2L\/\u03b2LIs, especially I\/R, is common in CRPA, particularly outside the USA and in carbapenemase-producing isolates. Additional treatment options are needed for CRPA infections.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.00388-25","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:20:26Z","timestamp":1778854826000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Resistance to novel \u03b2-lactam\/\u03b2-lactamase inhibitors among carbapenem-resistant\n                    <i>Pseudomonas aeruginosa<\/i>\n                    and clinical implications in the prospective observational\n                    <i>Pseudomonas<\/i>\n                    study"],"prefix":"10.1128","volume":"70","author":[{"given":"Lee S.","family":"Gottesdiener","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02r109517","id-type":"ROR","asserted-by":"publisher"}],"name":"Weill Cornell Medicine","place":["New York, USA"]},{"id":[{"id":"https:\/\/ror.org\/01j17xg39","id-type":"ROR","asserted-by":"publisher"}],"name":"NewYork-Presbyterian Hospital","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Li","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00y4zzh67","id-type":"ROR","asserted-by":"publisher"}],"name":"The Biostatistics Center, George Washington University","place":["Rockville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerryl E.","family":"Greenwood-Quaintance","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qp3tb03","id-type":"ROR","asserted-by":"publisher"}],"name":"Mayo Clinic","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Komarow","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00y4zzh67","id-type":"ROR","asserted-by":"publisher"}],"name":"The Biostatistics Center, George Washington University","place":["Rockville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9054-9774","authenticated-orcid":true,"given":"Cesar A.","family":"Arias","sequence":"additional","affiliation":[{"name":"Houston Methodist Hospital","place":["Houston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Cober","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03xjacd83","id-type":"ROR","asserted-by":"publisher"}],"name":"Cleveland Clinic","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica S.","family":"Herc","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0193sb042","id-type":"ROR","asserted-by":"publisher"}],"name":"Henry Ford Hospital","place":["Detroit, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith S.","family":"Kaye","sequence":"additional","affiliation":[{"name":"Rutgers Robert Wood Johnson Medical School","place":["New Brunswick, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Charles","family":"Huskins","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qp3tb03","id-type":"ROR","asserted-by":"publisher"}],"name":"Mayo Clinic","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jairo","family":"Figueroa","sequence":"additional","affiliation":[{"name":"Hospital Universitario Erasmo Meoz ESE","place":["C\u00facuta, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Vilchez","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0130frc33","id-type":"ROR","asserted-by":"publisher"}],"name":"University of North Carolina","place":["Chapel Hill, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6847-5518","authenticated-orcid":true,"given":"Bettina C.","family":"Fries","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05qghxh33","id-type":"ROR","asserted-by":"publisher"}],"name":"Stony Brook University","place":["Stony Brook, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Leroi","sequence":"additional","affiliation":[{"name":"The Austin Hospital","place":["Heidelberg West, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd P.","family":"McCarty","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/008s83205","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Alabama at Birmingham","place":["Birmingham, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda L.","family":"Rioseco","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Universidad San Sebasti\u00e1n, Sede Patagonia","place":["Concepci\u00f3n, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M.","family":"Munita","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Cl\u00ednica Alemana, Universidad del Desarrollo","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin E.","family":"Stryjewski","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04czhsq43","id-type":"ROR","asserted-by":"publisher"}],"name":"Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas","place":["Buenos Aires, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1722-0734","authenticated-orcid":true,"given":"Jinnethe","family":"Reyes","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04m9gzq43","id-type":"ROR","asserted-by":"publisher"}],"name":"Molecular Genetics and Antimicrobial Resistance Unit, Universidad El Bosque","place":["Bogot\u00e1, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5845-2235","authenticated-orcid":true,"given":"Liang","family":"Chen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01y64my43","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Pharmacy and Pharmaceutical Sciences, University at Buffalo","place":["Buffalo, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0243-131X","authenticated-orcid":true,"given":"Barry N.","family":"Kreiswirth","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00fgmrc59","id-type":"ROR","asserted-by":"publisher"}],"name":"Center for Discovery and Innovation, Hackensack Meridian Health","place":["Nutley, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Hill","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00py81415","id-type":"ROR","asserted-by":"publisher"}],"name":"Duke Clinical Research Institute, Duke University","place":["Durham, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keri","family":"Baum","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00py81415","id-type":"ROR","asserted-by":"publisher"}],"name":"Duke Clinical Research Institute, Duke University","place":["Durham, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1898-9067","authenticated-orcid":true,"given":"Maria Virginia","family":"Villegas","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04m9gzq43","id-type":"ROR","asserted-by":"publisher"}],"name":"Grupo de Investigaci\u00f3n en Resistencia Antimicrobiana y Epidemiolog\u00eda Hospitalaria, Universidad El Bosque","place":["Bogot\u00e1, Colombia"]},{"name":"Cl\u00ednica Imbanaco Grupo Quir\u00f3nsalud","place":["Cali, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2079-4437","authenticated-orcid":true,"given":"David L.","family":"Paterson","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05p52kj31","id-type":"ROR","asserted-by":"publisher"}],"name":"Royal Brisbane and Women\u2019s Hospital","place":["Brisbane, Australia"]},{"id":[{"id":"https:\/\/ror.org\/01tgyzw49","id-type":"ROR","asserted-by":"publisher"}],"name":"National University of Singapore","place":["Singapore, Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3299-894X","authenticated-orcid":true,"given":"Robert A.","family":"Bonomo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05dbx6743","id-type":"ROR","asserted-by":"publisher"}],"name":"Clinical Scientist Investigator, Medical and Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry F.","family":"Chambers","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043mz5j54","id-type":"ROR","asserted-by":"publisher"}],"name":"University of California San Francisco","place":["San Francisco, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8048-0897","authenticated-orcid":true,"suffix":"Jr.","given":"Vance G.","family":"Fowler","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00py81415","id-type":"ROR","asserted-by":"publisher"}],"name":"Duke Clinical Research Institute, Duke University","place":["Durham, USA"]},{"id":[{"id":"https:\/\/ror.org\/03njmea73","id-type":"ROR","asserted-by":"publisher"}],"name":"Duke University Medical Center","place":["Durham, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6344-4141","authenticated-orcid":true,"given":"Robin","family":"Patel","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qp3tb03","id-type":"ROR","asserted-by":"publisher"}],"name":"Mayo Clinic","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Doi","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine","place":["Pittsburgh, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4784-3227","authenticated-orcid":true,"given":"David","family":"van Duin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0130frc33","id-type":"ROR","asserted-by":"publisher"}],"name":"University of North Carolina","place":["Chapel Hill, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4711-5334","authenticated-orcid":true,"given":"Michael J.","family":"Satlin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02r109517","id-type":"ROR","asserted-by":"publisher"}],"name":"Weill Cornell Medicine","place":["New York, USA"]},{"id":[{"id":"https:\/\/ror.org\/01j17xg39","id-type":"ROR","asserted-by":"publisher"}],"name":"NewYork-Presbyterian Hospital","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Antibacterial Resistance Leadership Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00031-19"},{"key":"e_1_3_4_3_2","unstructured":"WHO. 2024. WHO bacterial priority pathogens list 2024: bacterial pathogens of public health importance to guide research development and strategies to prevent and control antimicrobial resistance. Media Center. Available from: https:\/\/www.who.int\/publications\/i\/item\/9789240093461. Retrieved 07 Mar 2024."},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jacamr\/dlad152"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2024.03.020"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad100"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz816"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm193"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00115-20"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30403-7"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30747-8"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa803"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-021-04308-0"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkaa456"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx453"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz147"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2021.115568"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad547"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(22)00329-9"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00825-15"},{"key":"e_1_3_4_21_2","volume-title":"CLSI supplement M100Performance standards for antimicrobial susceptibility testing","author":"CLSI","year":"2022","unstructured":"CLSI. 2022. CLSI supplement M100. Performance standards for antimicrobial susceptibility testing. 32nd ed. Clinical and Laboratory Standards Institute.","edition":"32"},{"key":"e_1_3_4_22_2","volume-title":"CLSI supplement M100Performance standards for antimicrobial susceptibility testing","author":"CLSI","year":"2025","unstructured":"CLSI. 2025. CLSI supplement M100. Performance standards for antimicrobial susceptibility testing. 35th ed. Clinical and Laboratory Standards Institute.","edition":"35"},{"key":"e_1_3_4_23_2","volume-title":"CLSI standard M07Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically","author":"CLSI","year":"2018","unstructured":"CLSI. 2018. CLSI standard M07. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. 11th ed. Clinical and Laboratory Standards Institute, Wayne, PA.","edition":"11"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkad396"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2023.106744"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01409-22"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1086\/338782"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01790-21"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw353"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00194-23"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkae329"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkab067"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07641-9"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00483-19"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.000131"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2008.03.002"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.2307\/2531493"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00388-25","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00388-25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T13:04:03Z","timestamp":1781787843000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.00388-25"}},"subtitle":[],"editor":[{"given":"Boudewijn L.","family":"de Jonge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,6,3]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,3]]}},"alternative-id":["10.1128\/aac.00388-25"],"URL":"https:\/\/doi.org\/10.1128\/aac.00388-25","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,3]]},"assertion":[{"value":"2025-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00388-25"}}