{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T02:54:04Z","timestamp":1777085644747,"version":"3.51.4"},"reference-count":25,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content content-type=\"genus-species\">Mycobacterium simiae<\/jats:named-content>\n            is a rare species of slow-growing nontuberculous mycobacteria (NTM). From 2002 to 2017, we conducted a retrospective study that included all patients with NTM-positive respiratory samples detected in two university hospitals of the French overseas department of Reunion Island. We recorded the prevalence of\n            <jats:named-content content-type=\"genus-species\">M. simiae<\/jats:named-content>\n            in this cohort, as well as the clinical, radiological, and microbiological features of patients with at least 1 sample positive for\n            <jats:named-content content-type=\"genus-species\">M. simiae<\/jats:named-content>\n            . In our cohort, 97 patients (15.1%) were positive for\n            <jats:named-content content-type=\"genus-species\">M. simiae<\/jats:named-content>\n            . Twenty-one patients (21.6%) met the American Thoracic Society (ATS) criteria for infection.\n            <jats:named-content content-type=\"genus-species\">M. simiae<\/jats:named-content>\n            infection was associated with bronchiectasis, micronodular lesions, and weight loss. Antibiotic susceptibility testing was performed for 60 patients, and the isolates were found to have low susceptibility to antibiotics, except for amikacin, fluoroquinolones, and clarithromycin. Treatment failed for 4 of the 8 patients treated for\n            <jats:named-content content-type=\"genus-species\">M. simiae<\/jats:named-content>\n            infection. Here, we describe a specific cluster corresponding to a large cohort of patients with\n            <jats:named-content content-type=\"genus-species\">M. simiae<\/jats:named-content>\n            , a rare nontuberculous mycobacterium associated with low pathogenicity and poor susceptibility to antibiotics.\n          <\/jats:p>","DOI":"10.1128\/aac.00395-18","type":"journal-article","created":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T09:32:34Z","timestamp":1525944754000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":32,"title":["Clinical, Radiological, and Microbiological Characteristics of Mycobacterium simiae Infection in 97 Patients"],"prefix":"10.1128","volume":"62","author":[{"given":"Nathalie","family":"Coolen-Allou","sequence":"first","affiliation":[{"name":"Service de Pneumologie, CHU La R\u00e9union Site F\u00e9lix Guyon, Saint Denis, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Touron","sequence":"additional","affiliation":[{"name":"Service de Pneumologie, CHU La R\u00e9union Site F\u00e9lix Guyon, Saint Denis, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Belmonte","sequence":"additional","affiliation":[{"name":"Service de Microbiologie, CHU La R\u00e9union Site F\u00e9lix Guyon, Saint Denis, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virgile","family":"Gazaille","sequence":"additional","affiliation":[{"name":"Service de Pneumologie, CHU La R\u00e9union Site F\u00e9lix Guyon, Saint Denis, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Andre","sequence":"additional","affiliation":[{"name":"Service de Pneumologie, CHU La R\u00e9union Site F\u00e9lix Guyon, Saint Denis, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"Allyn","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation M\u00e9dicale, CHU La R\u00e9union Site F\u00e9lix Guyon, Saint Denis, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Picot","sequence":"additional","affiliation":[{"name":"Service de Microbiologie, CHU La R\u00e9union Site Sud R\u00e9union, Saint Pierre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annabelle","family":"Payet","sequence":"additional","affiliation":[{"name":"Service de Pneumologie, CHU La R\u00e9union Site Sud R\u00e9union, Saint Pierre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Veziris","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9s, UPMC Universitaire de Paris 06, INSERM, Centre d'Immunologie et des Maladies Infectieuses, UMR 1135, Paris, France"},{"name":"D\u00e9partement de Bact\u00e9riologie, H\u00f4pitaux Universitaires de l'Est Parisien, Centre National de R\u00e9f\u00e9rence des Mycobact\u00e9ries, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200604-571ST"},{"key":"e_1_3_1_3_2","first-page":"275","article-title":"Occurrence of atypical mycobacteria in Macacus rhesus","volume":"12","author":"Karassova V","year":"1965","unstructured":"Karassova V, Weissfeiler J, Krasznay E. 1965. 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