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Some derivatives inhibit phosphodiesterases (PDEs) and thereby increase the cellular concentration of cyclic AMP (cAMP), which plays a vital role in the control of metabolism in eukaryotic cells, including the protozoan\n            <jats:named-content content-type=\"genus-species\">Trypanosoma cruzi<\/jats:named-content>\n            , the etiological agent of Chagas disease (CD), a major neglected tropical disease.\n            <jats:italic>In vitro<\/jats:italic>\n            phenotypic screening identified a 4-bromophenyl-dihydropyrazole dimer as an anti-\n            <jats:named-content content-type=\"genus-species\">T. cruzi<\/jats:named-content>\n            hit and 17 novel pyrazolone analogues with variations on the phenyl ring were investigated in a panel of phenotypic laboratory models.\n          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