{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T01:25:25Z","timestamp":1778203525507,"version":"3.51.4"},"reference-count":28,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Chinese Key Research and Development Plan","award":["2016YFD0501305"],"award-info":[{"award-number":["2016YFD0501305"]}]},{"name":"Chinese Special Fund for Agro-scientific Research","award":["201303044"],"award-info":[{"award-number":["201303044"]}]},{"name":"China Agriculture Research System","award":["CARS-42-G11"],"award-info":[{"award-number":["CARS-42-G11"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Sequence analysis of 79 ciprofloxacin-resistant\n            <jats:named-content content-type=\"genus-species\">Campylobacter jejuni<\/jats:named-content>\n            isolates collected in China showed resistance-related sequence variations in\n            <jats:italic>gyrA<\/jats:italic>\n            and CmeR-Box. All the isolates contain an identical Thr-86-Ile substitution in GyrA. Several novel CmeR-Box variations, including point substitutions, deletion, and insertion, were identified. The point insertion or deletion led to dramatically reduced binding of CmeR to the\n            <jats:italic>cmeABC<\/jats:italic>\n            promoter, which significantly increases the expression of\n            <jats:italic>cmeABC<\/jats:italic>\n            and contributes to the high fluoroquinolone resistance.\n          <\/jats:p>","DOI":"10.1128\/aac.00422-17","type":"journal-article","created":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T00:55:26Z","timestamp":1493081726000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Correlation between\n            <i>gyrA<\/i>\n            and CmeR Box Polymorphism and Fluoroquinolone Resistance in Campylobacter jejuni Isolates in China"],"prefix":"10.1128","volume":"61","author":[{"given":"Tengfei","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Prevention and Control Agents for Animal Bacteriosis, Institute of 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