{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:37:47Z","timestamp":1792132667888,"version":"4.4.0"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2023,6,15]]},"abstract":"<jats:p>\n            We determined the echinocandin susceptibility and\n            <jats:italic>FKS1<\/jats:italic>\n            genotypes of 13 clinical isolates of\n            <jats:named-content content-type=\"genus-species\">Candida auris<\/jats:named-content>\n            that were recovered from 4 patients at a tertiary care center in Salvador, Brazil. Three isolates were categorized as echinocandin-resistant, and they harbored a novel\n            <jats:italic>FKS1<\/jats:italic>\n            mutation that led to an amino acid change W691L located downstream from hot spot 1.\n          <\/jats:p>","DOI":"10.1128\/aac.00423-23","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T14:02:35Z","timestamp":1684936955000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":30,"title":["Novel Non-Hot Spot Modification in Fks1 of Candida auris Confers Echinocandin Resistance"],"prefix":"10.1128","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8479-0721","authenticated-orcid":true,"given":"Milena","family":"Kordalewska","sequence":"first","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geselle","family":"Cancino-Prado","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3766-026X","authenticated-orcid":true,"given":"Jo\u00e3o","family":"Nobrega de Almeida J\u00fanior","sequence":"additional","affiliation":[{"name":"Escola Paulista de Medicina, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Hospital Israelita Albert Einstein, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Brasil Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Hospital da Bahia, Salvador, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Tigulini de Souza Peral","sequence":"additional","affiliation":[{"name":"Brazilian Ministry of Health, Bras\u00edlia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaldo L.","family":"Colombo","sequence":"additional","affiliation":[{"name":"Escola Paulista de Medicina, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9503-3184","authenticated-orcid":false,"given":"David S.","family":"Perlin","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12831"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.20411\/pai.v7i2.535"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.03333-20"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01243-22"},{"key":"e_1_3_2_6_2","volume-title":"Reference method for broth dilution antifungal susceptibility testing of yeasts.","author":"CLSI","year":"2017","unstructured":"CLSI. 2017. Reference method for broth dilution antifungal susceptibility testing of yeasts. 4th ed CLSI standard M27. Clinical and Laboratory Standards Institute, Wayne, PA.","edition":"4"},{"key":"e_1_3_2_7_2","volume-title":"Performance Standards for Antifungal Susceptibility Testing of Yeasts.","author":"CLSI","year":"2020","unstructured":"CLSI. 2020. Performance Standards for Antifungal Susceptibility Testing of Yeasts. 2nd ed CLSI supplement M60. Clinical and Laboratory Standards Institute, Wayne, PA.","edition":"2"},{"key":"e_1_3_2_8_2","unstructured":"CDC. 2020. Antifungal susceptibility testing and interpretation on Centers for Disease Control and Prevention. https:\/\/www.cdc.gov\/fungal\/candida-auris\/c-auris-antifungal.html. Accessed 03 August 2023."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00238-18"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00082-12"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00833-17"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2022.04.003"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00218-17"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2019.1684209"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05856-5"},{"key":"e_1_3_2_16_2","article-title":"Molecular epidemiology of Candida auris outbreak in a major secondary-care hospital in Kuwait","volume":"6","author":"Alfouzan W","year":"2020","unstructured":"Alfouzan W, Ahmad S, Dhar R, Asadzadeh M, Almerdasi N, Abdo NM, Joseph L, de Groot T, Alali Wq Khan Z, Meis JF, Al-Rashidi MR. 2020. Molecular epidemiology of Candida auris outbreak in a major secondary-care hospital in Kuwait. J Fungi (Basel) 6.","journal-title":"J Fungi (Basel)"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01652-21"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13419"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofz262"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(20)30090-2"},{"key":"e_1_3_2_21_2","article-title":"Fatal breakthrough candidemia in an immunocompromised patient in Kuwait due to Candida auris exhibiting reduced susceptibility to echinocandins and carrying a novel mutation in hotspot-1 of FKS1","volume":"8","author":"Al-Obaid I","year":"2022","unstructured":"Al-Obaid I, Asadzadeh M, Ahmad S, Alobaid K, Alfouzan W, Bafna R, Emara M, Joseph L. 2022. Fatal breakthrough candidemia in an immunocompromised patient in Kuwait due to Candida auris exhibiting reduced susceptibility to echinocandins and carrying a novel mutation in hotspot-1 of FKS1. J Fungi (Basel) 8.","journal-title":"J Fungi (Basel)"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2018.0408"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00423-23","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00423-23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T13:05:01Z","timestamp":1686834301000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.00423-23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,15]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6,15]]}},"alternative-id":["10.1128\/aac.00423-23"],"URL":"https:\/\/doi.org\/10.1128\/aac.00423-23","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,15]]},"assertion":[{"value":"2023-03-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00423-23"}}