{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:40:53Z","timestamp":1790685653487,"version":"4.1.0"},"reference-count":18,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Of 3,004 gram-negative bacilli collected from intra-abdominal infections in the Asia-Pacific region during 2007, 42.2% and 35.8% of<jats:italic>Escherichia coli<\/jats:italic>and<jats:italic>Klebsiella<\/jats:italic>spp., respectively, were extended-spectrum \u03b2-lactamase (ESBL) positive. Moreover ESBL rates in India for<jats:italic>E. coli<\/jats:italic>,<jats:italic>Klebsiella pneumoniae<\/jats:italic>, and<jats:italic>Klebsiella oxytoca<\/jats:italic>were 79.0%, 69.4%, and 100%, respectively. ESBL-positive<jats:italic>E. coli<\/jats:italic>rates were also relatively high in China (55.0%) and Thailand (50.8%). Ertapenem and imipenem were the most active drugs tested, inhibiting over 90% of all species, including ESBL-positive isolates with the exception of<jats:italic>Pseudomonas aeruginosa<\/jats:italic>isolates (&lt;90% susceptible to all study drugs) and ESBL-positive<jats:italic>Klebsiella pneumoniae<\/jats:italic>isolates (&lt;90% susceptible to all study drugs except imipenem). Quinolones achieved 90% inhibition levels only against ESBL-negative<jats:italic>K. pneumoniae<\/jats:italic>and ESBL-negative<jats:italic>K. oxytoca<\/jats:italic>. A decline in ampicillin-sulbactam activity was noted, with only 34.5% of all<jats:italic>Enterobacteriaceae<\/jats:italic>inhibited in this study.<\/jats:p>","DOI":"10.1128\/aac.00426-09","type":"journal-article","created":{"date-parts":[[2009,6,9]],"date-time":"2009-06-09T01:49:59Z","timestamp":1244512199000},"page":"3280-3284","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":167,"title":["Emergence of High Levels of Extended-Spectrum-\u03b2-Lactamase-Producing Gram-Negative Bacilli in the Asia-Pacific Region: Data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) Program, 2007"],"prefix":"10.1128","volume":"53","author":[{"given":"Stephen P.","family":"Hawser","sequence":"first","affiliation":[{"name":"IHMA, 1066 Epalinges, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel K.","family":"Bouchillon","sequence":"additional","affiliation":[{"name":"International Health Management Associates, Inc., Schaumburg, Illinois 60173-3817"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryl J.","family":"Hoban","sequence":"additional","affiliation":[{"name":"International Health Management Associates, Inc., Schaumburg, Illinois 60173-3817"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Badal","sequence":"additional","affiliation":[{"name":"International Health Management Associates, Inc., Schaumburg, Illinois 60173-3817"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Ren","family":"Hsueh","sequence":"additional","affiliation":[{"name":"Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Paterson","sequence":"additional","affiliation":[{"name":"University of Queensland, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2003.09.002"},{"key":"e_1_3_2_3_2","unstructured":"Abstr. 48th Intersci. 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