{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T22:36:20Z","timestamp":1772231780633,"version":"3.50.1"},"reference-count":14,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Two patients with severe sepsis due to panresistant\n            <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n            , deteriorating despite therapy with colistin and \u03b2-lactams, were cured with a high daily dose (25 to 50 mg\/kg) of amikacin to obtain a peak\/MIC ratio of at least 8 to 10 (MIC = 16 \u03bcg\/ml). Concomitant use of continuous venovenous hemodiafiltration (CVVHDF) provided no deterioration in renal function after treatment. High dosage of aminoglycosides combined with CVVHDF may represent a valuable therapeutic option for infection due to multiresistant pathogens.\n          <\/jats:p>","DOI":"10.1128\/aac.00441-10","type":"journal-article","created":{"date-parts":[[2010,9,8]],"date-time":"2010-09-08T02:45:29Z","timestamp":1283913929000},"page":"4939-4941","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":44,"title":["Amikacin Monotherapy for Sepsis Caused by Panresistant\n            <i>Pseudomonas aeruginosa<\/i>"],"prefix":"10.1128","volume":"54","author":[{"given":"Brice","family":"Layeux","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio Silvio","family":"Taccone","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Erasme Hospital, Universite\u0301 Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Fagnoul","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Erasme Hospital, Universite\u0301 Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Louis","family":"Vincent","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Erasme Hospital, Universite\u0301 Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fre\u0301de\u0301rique","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199426060-00004"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/520991"},{"key":"e_1_3_2_4_2","unstructured":"European Committee on Antibiotic Susceptibility Testing (EUCAST). 2009"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2006.12.012"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00040-09"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/155.1.93"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.2005.25.10.1353"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2009.08.006"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e31818b6b2f"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.7.1549"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(04)01108-9"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31819ced02"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc8945"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/444500"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00441-10","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00441-10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:15:36Z","timestamp":1645474536000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00441-10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":14,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["10.1128\/AAC.00441-10"],"URL":"https:\/\/doi.org\/10.1128\/aac.00441-10","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11]]},"assertion":[{"value":"2010-04-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-08-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}