{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:36:20Z","timestamp":1791423380886,"version":"4.3.3"},"reference-count":37,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Isolates of\n                    <jats:italic>Salmonella enterica<\/jats:italic>\n                    serovar Typhi that are multidrug resistant (MDR, resistant to chloramphenicol, ampicillin, and trimethoprim-sulfamethoxazole) and have reduced susceptibility to fluoroquinolones (nalidixic acid resistant, Na\n                    <jats:sup>r<\/jats:sup>\n                    ) are common in Asia. The optimum treatment for infections caused by such isolates is not established. This study compared different antimicrobial regimens for the treatment of MDR\/Na\n                    <jats:sup>r<\/jats:sup>\n                    typhoid fever. Vietnamese children and adults with uncomplicated typhoid fever were entered into an open randomized controlled trial. Ofloxacin (20 mg\/kg of body weight\/day for 7 days), azithromycin (10 mg\/kg\/day for 7 days), and ofloxacin (15 mg\/kg\/day for 7 days) combined with azithromycin (10 mg\/kg\/day for the first 3 days) were compared. Of the 241 enrolled patients, 187 were eligible for analysis (186\n                    <jats:italic>S. enterica<\/jats:italic>\n                    serovar Typhi, 1\n                    <jats:italic>Salmonella enterica<\/jats:italic>\n                    serovar Paratyphi A). Eighty-seven percent (163\/187) of the patients were children; of the\n                    <jats:italic>S. enterica<\/jats:italic>\n                    serovar Typhi isolates, 88% (165\/187) were MDR and 93% (173\/187) were Na\n                    <jats:sup>r<\/jats:sup>\n                    . The clinical cure rate was 64% (40\/63) with ofloxacin, 76% (47\/62) with ofloxacin-azithromycin, and 82% (51\/62) with azithromycin (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.053). The mean (95% confidence interval [CI]) fever clearance time for patients treated with azithromycin (5.8 days [5.1 to 6.5 days]) was shorter than that for patients treated with ofloxacin-azithromycin (7.1 days [6.2 to 8.1 days]) and ofloxacin (8.2 days [7.2 to 9.2 days]) (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001). Positive fecal carriage immediately posttreatment was detected in 19.4% (12\/62) of patients treated with ofloxacin, 6.5% (4\/62) of those treated with the combination, and 1.6% (1\/62) of those treated with azithromycin (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.006). Both antibiotics were well tolerated. Uncomplicated typhoid fever due to isolates of MDR\n                    <jats:italic>S. enterica<\/jats:italic>\n                    serovar Typhi with reduced susceptibility to fluoroquinolones (Na\n                    <jats:sup>r<\/jats:sup>\n                    ) can be successfully treated with a 7-day course of azithromycin.\n                  <\/jats:p>","DOI":"10.1128\/aac.00447-06","type":"journal-article","created":{"date-parts":[[2006,12,4]],"date-time":"2006-12-04T20:33:47Z","timestamp":1165264427000},"page":"819-825","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":129,"title":["Randomized Controlled Comparison of Ofloxacin, Azithromycin, and an Ofloxacin-Azithromycin Combination for Treatment of Multidrug-Resistant and Nalidixic Acid-Resistant Typhoid Fever"],"prefix":"10.1128","volume":"51","author":[{"given":"Christopher M.","family":"Parry","sequence":"first","affiliation":[{"name":"Oxford University Clinical Research Unit"},{"name":"Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vo Anh","family":"Ho","sequence":"additional","affiliation":[{"name":"Dong Thap Provincial Hospital, Cao Lanh City, Dong Thap Province, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Thi","family":"Phuong","sequence":"additional","affiliation":[{"name":"Dong Thap Provincial Hospital, Cao Lanh City, Dong Thap Province, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phan Van Be","family":"Bay","sequence":"additional","affiliation":[{"name":"Dong Thap Provincial Hospital, Cao Lanh City, Dong Thap Province, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai Ngoc","family":"Lanh","sequence":"additional","affiliation":[{"name":"Dong Thap Provincial Hospital, Cao Lanh City, Dong Thap Province, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Thanh","family":"Tung","sequence":"additional","affiliation":[{"name":"Dong Thap Provincial Hospital, Cao Lanh City, Dong Thap Province, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thi Hong","family":"Tham","sequence":"additional","affiliation":[{"name":"Dong Thap Provincial Hospital, Cao Lanh City, Dong Thap Province, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Wain","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit"},{"name":"Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran Tinh","family":"Hien","sequence":"additional","affiliation":[{"name":"Hospital for Tropical Diseases, Ho Chi Minh City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy J.","family":"Farrar","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit"},{"name":"Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.2.827-829.2003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.20.2668"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.9.2167"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.74.1.44"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.2.450-452.2000"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.5.1775-1781.2005"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/47.4.455"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/44.2.243"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199903000-00007"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.7.1855-1859.2000"},{"key":"e_1_3_2_12_2","first-page":"353","volume":"333","year":"2006","unstructured":"Cooke, F. 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