{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:58:26Z","timestamp":1791097106569,"version":"4.1.0"},"reference-count":27,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We show that RsAFP2, a plant defensin that interacts with fungal glucosylceramides, is active against\n            <jats:italic>Candida albicans<\/jats:italic>\n            , inhibits to a lesser extent other\n            <jats:italic>Candida<\/jats:italic>\n            species, and is nontoxic to mammalian cells. Moreover, glucosylceramide levels in\n            <jats:italic>Candida<\/jats:italic>\n            species correlate with RsAFP2 sensitivity. We found RsAFP2 prophylactically effective against murine candidiasis.\n          <\/jats:p>","DOI":"10.1128\/aac.00448-08","type":"journal-article","created":{"date-parts":[[2008,9,30]],"date-time":"2008-09-30T00:54:41Z","timestamp":1222736081000},"page":"4522-4525","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":78,"title":["In Vitro Activity of the Antifungal Plant Defensin RsAFP2 against\n            <i>Candida<\/i>\n            Isolates and Its In Vivo Efficacy in Prophylactic Murine Models of Candidiasis"],"prefix":"10.1128","volume":"52","author":[{"given":"Patricia M.","family":"Tavares","sequence":"first","affiliation":[{"name":"Laborato\u0301rio de Estudos Integrados em Bioqui\u0301mica Microbiana, Instituto de Microbiologia Professor Paulo de Go\u0301es, Universidade Federal do Rio de Janeiro, Cidade Universita\u0301ria, CCS, Bloco I, Ilha do Funda\u0303o, Rio de Janeiro, RJ 21941590, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Thevissen","sequence":"additional","affiliation":[{"name":"Centre of Microbial and Plant Genetics (CMPG), Katholieke Universiteit Leuven, Kasteelpark Arenberg 20, 3001 Heverlee, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno P. 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