{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:34:33Z","timestamp":1761561273317},"reference-count":13,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Sixty days of ciprofloxacin administration at 500 mg every 12 h is currently recommended for the prophylaxis of inhalational exposure to\n            <jats:italic>Bacillus anthracis<\/jats:italic>\n            . We examined\n            <jats:italic>Bacillus anthracis<\/jats:italic>\n            (\u0394-Sterne strain) in our hollow-fiber infection model. We measured the ciprofloxacin concentrations achieved and the number of organisms present before heat shock (total population) and after heat shock (spore population). We fit a mathematical model to these data. Monte Carlo simulation with differing initial spore burdens (3, 5, and 6.9 log\n            <jats:sub>10<\/jats:sub>\n            CFU\/ml) demonstrated that 35 days of this regimen would completely clear the spore burden in 95% of patients. Durations of 110 days did not achieve 99.9% eradication, irrespective of initial burden, because of between-patient variance in drug pharmacokinetics. Given the absence of person-to-person transmission for\n            <jats:italic>Bacillus anthracis<\/jats:italic>\n            , adverse drug effects with long-term ciprofloxacin administration, and the possibility of engendering resistance in bodily flora, shorter prophylaxis duration should be given consideration, along with careful monitoring of all exposed individuals.\n          <\/jats:p>","DOI":"10.1128\/aac.00453-08","type":"journal-article","created":{"date-parts":[[2008,8,26]],"date-time":"2008-08-26T00:45:17Z","timestamp":1219711517000},"page":"3973-3979","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Is 60 Days of Ciprofloxacin Administration Necessary for Postexposure Prophylaxis for\n            <i>Bacillus anthracis<\/i>\n            ?"],"prefix":"10.1128","volume":"52","author":[{"given":"G. L.","family":"Drusano","sequence":"first","affiliation":[{"name":"Ordway Research Institute, Laboratory of Emerging Infections, Albany, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olanrewaju O.","family":"Okusanya","sequence":"additional","affiliation":[{"name":"Institute for Clinical Pharmacodynamics of Ordway Research Institute, Albany, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adedoyin","family":"Okusanya","sequence":"additional","affiliation":[{"name":"Ordway Research Institute, Laboratory of Emerging Infections, Albany, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Van Scoy","sequence":"additional","affiliation":[{"name":"Ordway Research Institute, Laboratory of Emerging Infections, Albany, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. L.","family":"Brown","sequence":"additional","affiliation":[{"name":"Ordway Research Institute, Laboratory of Emerging Infections, Albany, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Kulawy","sequence":"additional","affiliation":[{"name":"Ordway Research Institute, Laboratory of Emerging Infections, Albany, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fritz","family":"So\u0308rgel","sequence":"additional","affiliation":[{"name":"Institute for Biomedical and Pharmaceutical Research, Nu\u0308rnberg-Heroldsberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry S.","family":"Heine","sequence":"additional","affiliation":[{"name":"United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702-5011"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnold","family":"Louie","sequence":"additional","affiliation":[{"name":"Ordway Research Institute, Laboratory of Emerging Infections, Albany, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0906.030118"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1631983100"},{"key":"e_1_3_2_4_2","unstructured":"Methods for dilutional antimicrobial susceptibility testing for bacteria that grow aerobically; approved standard 2006"},{"key":"e_1_3_2_5_2","unstructured":"ADAPT II. 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Medical counterbioterrorism: the response to provide anthrax prophylaxis to New York City US Postal Service employees. Ann. Emerg. Med.41:441-446.","journal-title":"Ann. Emerg. Med."},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1086\/518151","volume":"45","year":"2007","unstructured":"Russell, P. K. 2007. Project Bioshield: what it is, why it is needed and its accomplishments so far. Clin. Infect. Dis.45(Suppl. 1):S68-S72.","journal-title":"Clin. Infect. Dis."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00453-08","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00453-08","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T19:30:06Z","timestamp":1645471806000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00453-08"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":13,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["10.1128\/AAC.00453-08"],"URL":"https:\/\/doi.org\/10.1128\/aac.00453-08","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11]]},"assertion":[{"value":"2008-04-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-08-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}