{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T01:21:46Z","timestamp":1776475306119,"version":"3.51.2"},"reference-count":28,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100003973","name":"Israel Academy of Sciences and Humanities","doi-asserted-by":"publisher","award":["2444\/18"],"award-info":[{"award-number":["2444\/18"]}],"id":[{"id":"10.13039\/501100003973","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2022,8,16]]},"abstract":"<jats:p>\n            Invasive aspergillosis (IA), caused predominantly by\n            <jats:named-content content-type=\"genus-species\">Aspergillus fumigatus<\/jats:named-content>\n            , is the most common opportunistic mold infection in immunocompromised patients. Resistance of\n            <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n            to triazoles has been increasingly reported, leading to poor outcomes of IA to the front-line azoles.\n          <\/jats:p>","DOI":"10.1128\/aac.00458-22","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T13:01:54Z","timestamp":1658322114000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["Triazole Priming as an Adaptive Response and Gateway to Resistance in Aspergillus fumigatus"],"prefix":"10.1128","volume":"66","author":[{"given":"Ety","family":"Harish","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Argha","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Handelman","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amar","family":"Abo Kandil","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yana","family":"Shadkchan","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7784-7256","authenticated-orcid":true,"given":"Sebastian","family":"Wurster","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health, University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8051-2940","authenticated-orcid":true,"given":"Dimitrios P.","family":"Kontoyiannis","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health, University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0433-0096","authenticated-orcid":true,"given":"Nir","family":"Osherov","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/brv.12215"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/pce.13526"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12521"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1154456"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.13223"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08112"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e07-07-0680"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000488"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.112.143016"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.funeco.2016.02.002"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074951"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01896-18"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01414-20"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/g3journal\/jkab208"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-021-00922-y"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004404"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00140-18"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.15274"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myaa075"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031801"},{"key":"e_1_3_2_22_2","volume-title":"Reference method for broth dilution antifungal susceptibility testing of filamentous fungi","author":"Clinical and Laboratory Standards Institute","year":"2017","unstructured":"Clinical and Laboratory Standards Institute. 2017. Reference method for broth dilution antifungal susceptibility testing of filamentous fungi, 3rd ed. CLSI standard M38. Clinical and Laboratory Standards Institute, Wayne, PA.","edition":"3"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01024"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy473"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2009.01803.x"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00188-17"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2011.631946"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-019-0322-2"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2018.2886"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00458-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00458-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T13:06:27Z","timestamp":1660655187000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.00458-22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,16]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8,16]]}},"alternative-id":["10.1128\/aac.00458-22"],"URL":"https:\/\/doi.org\/10.1128\/aac.00458-22","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,16]]},"assertion":[{"value":"2022-03-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00458-22"}}