{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:46:58Z","timestamp":1785851218063,"version":"3.56.0"},"reference-count":27,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01HL154998"],"award-info":[{"award-number":["P01HL154998"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI158530"],"award-info":[{"award-number":["R01AI158530"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL149883"],"award-info":[{"award-number":["R01HL149883"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01LM013337"],"award-info":[{"award-number":["R01LM013337"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI174159"],"award-info":[{"award-number":["R21AI174159"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01TR003528"],"award-info":[{"award-number":["U01TR003528"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AI135964"],"award-info":[{"award-number":["U19AI135964"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2026,8,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Population pharmacokinetic (PK) models may not generalize across critically ill populations. We evaluated the transportability of published parametric and nonparametric meropenem models as Bayesian priors. Seven published meropenem models were implemented in Monolix 2024R1. Nonparametric models were converted to log-normal priors from reported medians and CV%. An independent cohort was used for evaluation.\n                      <jats:italic toggle=\"yes\">A priori<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">a posteriori<\/jats:italic>\n                      predictions were summarized across eligible observations and separately for observations obtained during continuous renal replacement therapy (CRRT) and in the absence of CRRT. Predictive performance was assessed using relative mean prediction error (rMPE) and relative median absolute prediction error (rMdAPE). An rMPE within \u00b120% and an rMdAPE \u226430% were defined as acceptable. Seventeen patients, including six receiving CRRT, contributed 74 plasma concentrations. In the pooled cohort, only the Rohani and Shekar models met predefined performance thresholds at both population and individual levels (\n                      <jats:italic toggle=\"yes\">a priori<\/jats:italic>\n                      rMdAPE 24.6%\u201326.4%;\n                      <jats:italic toggle=\"yes\">a posteriori<\/jats:italic>\n                      rMdAPE 6.7%\u201311.1%). In CRRT patients, no model achieved acceptable\n                      <jats:italic toggle=\"yes\">a priori<\/jats:italic>\n                      performance; after Bayesian updating, all CRRT-specified models met accuracy and precision criteria, with the nonparametric models (Reed and Rohani) demonstrating low imprecision. In non-CRRT patients, several models showed population-level bias, but all met predefined accuracy and precision thresholds after Bayesian updating. Among evaluated models, Rohani, Reed, and Shekar demonstrated the most consistent predictive performance across the CRRT and non-CRRT subgroups. Nonparametric model summaries can be translated into parametric priors, but model selection remains critical when applying Bayesian dosing in critically ill patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.00458-26","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:01:32Z","timestamp":1783695692000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Predictive accuracy of population meropenem models in critically ill pneumonia patients"],"prefix":"10.1128","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4192-5229","authenticated-orcid":true,"given":"Adrian","family":"Valadez","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00t30ch44","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmacy Practice, Midwestern University, College of Pharmacy","place":["Downers Grove, USA"]},{"id":[{"id":"https:\/\/ror.org\/00t30ch44","id-type":"ROR","asserted-by":"publisher"}],"name":"Pharmacometrics Center of Excellence, Midwestern University","place":["Downers Grove, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Harlan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00t30ch44","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmacy Practice, Midwestern University, College of Pharmacy","place":["Downers Grove, USA"]},{"id":[{"id":"https:\/\/ror.org\/00t30ch44","id-type":"ROR","asserted-by":"publisher"}],"name":"Pharmacometrics Center of Excellence, Midwestern University","place":["Downers Grove, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Jeantet","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00t30ch44","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmacy Practice, Midwestern University, College of Pharmacy","place":["Downers Grove, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1091-6130","authenticated-orcid":true,"given":"Marc H.","family":"Scheetz","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00t30ch44","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmacy Practice, Midwestern University, College of Pharmacy","place":["Downers Grove, USA"]},{"id":[{"id":"https:\/\/ror.org\/00t30ch44","id-type":"ROR","asserted-by":"publisher"}],"name":"Pharmacometrics Center of Excellence, Midwestern University","place":["Downers Grove, USA"]},{"id":[{"id":"https:\/\/ror.org\/009543z50","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmacy, Northwestern Memorial Hospital","place":["Chicago, USA"]},{"name":"Department of Biomedical Sciences, College of Graduate Studies, Midwestern University","place":["Downers Grove, USA"]},{"name":"Department of Pharmacology, College of Graduate Studies, Midwestern University","place":["Downers Grove, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1675-8276","authenticated-orcid":true,"given":"Michael N.","family":"Neely","sequence":"additional","affiliation":[{"name":"Keck School of Medicine, University of Southern California","place":["Los Angeles, USA"]},{"id":[{"id":"https:\/\/ror.org\/0511k4970","id-type":"ROR","asserted-by":"publisher"}],"name":"Laboratory of Applied Pharmacokinetics and Bioinformatics, The Saban Research Institute, Children's Hospital of Los Angeles","place":["Los Angeles, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8827-8581","authenticated-orcid":true,"given":"Helen K.","family":"Donnelly","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00m6w7z96","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine","place":["Chicago, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard G.","family":"Wunderink","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00m6w7z96","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine","place":["Chicago, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0018-5434","authenticated-orcid":true,"given":"Nathaniel J.","family":"Rhodes","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00t30ch44","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmacy Practice, Midwestern University, College of Pharmacy","place":["Downers Grove, 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Successful Clinical Response in Pneumonia Therapy (SCRIPT). Northwestern University. Available from: https:\/\/script.northwestern.edu\/database\/. Retrieved 3030 JunJune 2026. Accessed 3030 JunJune 2026"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000180580"},{"key":"e_1_3_5_17_2","unstructured":"U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) Center for Veterinary Medicine (CVM). 2018. Rockville MD Food and Drug Administration (FDA)"},{"key":"e_1_3_5_18_2","unstructured":"Avantor. Acetonitrile \u226599.9% OmniSolv for LC-MS Supelco. Available from: https:\/\/us.vwr.com\/store\/catalog\/product.jsp?catalog_number=EM-AX0156-1. Retrieved 3030 JunJune 2026. Accessed 3030 JunJune 2026"},{"key":"e_1_3_5_19_2","unstructured":"Monolix 2024R1. 2024 Available from: https:\/\/www.simulations-plus.com\/software\/monolix\/monolix"},{"key":"e_1_3_5_20_2","unstructured":"Elassaiss-Schaap J Heisterkamp S. 2009. Variability as constant coefficient of variation: can we right two decades in error? Petersburg RU abstr PAGE"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00002"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01061030"},{"key":"e_1_3_5_24_2","unstructured":"R Core Team. 2025. R: a language and environment for statistical computing. R Foundation for Statistical Computing. https:\/\/www.R-project.org."},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.12353"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2025.05.015"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00104-23"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.838205"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00458-26","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00458-26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:03:10Z","timestamp":1785848590000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.00458-26"}},"subtitle":[],"editor":[{"given":"Vincent H.","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,8,5]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8,5]]}},"alternative-id":["10.1128\/aac.00458-26"],"URL":"https:\/\/doi.org\/10.1128\/aac.00458-26","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,5]]},"assertion":[{"value":"2026-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00458-26"}}