{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:40:33Z","timestamp":1790714433477,"version":"4.1.0"},"reference-count":57,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2011,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n A 13-month prospective multicenter study including 44 hospitals was carried out to evaluate the epidemiology of\n Candida parapsilosis<\/jats:named-content>\n complex candidemia in Spain. Susceptibility to amphotericin B, flucytosine, fluconazole, itraconazole, voriconazole, posaconazole, anidulafungin, caspofungin, and micafungin was tested by the microdilution colorimetric method. A total of 364\n C. parapsilosis<\/jats:named-content>\n complex isolates were identified by molecular methods:\n C. parapsilosis<\/jats:named-content>\n (90.7%),\n Candida orthopsilosis<\/jats:named-content>\n (8.2%), and\n Candida metapsilosis<\/jats:named-content>\n (1.1%). Most candidemias (\n C. parapsilosis<\/jats:named-content>\n , 76.4%;\n C. orthopsilosis<\/jats:named-content>\n , 70.0%;\n C. metapsilosis<\/jats:named-content>\n , 100%) were observed in adults. No\n C. orthopsilosis<\/jats:named-content>\n or\n C. metapsilosis<\/jats:named-content>\n candidemias occurred in neonates.\n C. parapsilosis<\/jats:named-content>\n was most frequent in adult intensive care unit (28.8%), surgery (20.9%), and internal medicine (19.7%) departments; and\n C. orthopsilosis<\/jats:named-content>\n was most frequent in hematology (28.6%), pediatrics (12.0%), and neonatology (11.5%) departments. The geographic distribution of\n C. orthopsilosis<\/jats:named-content>\n and\n C. metapsilosis<\/jats:named-content>\n was not uniform. According to CLSI clinical breakpoints, all\n C. orthopsilosis<\/jats:named-content>\n and\n C. metapsilosis<\/jats:named-content>\n isolates were susceptible to the nine agents tested. Resistance (MICs > 1 mg\/liter) was observed only in\n C. parapsilosis<\/jats:named-content>\n : amphotericin B, posaconazole, itraconazole, and caspofungin (0.3% each), anidulafungin (1.9%), and micafungin (2.5%). Applying the new species-specific fluconazole and echinocandin breakpoints, the rates of resistance to fluconazole for\n C. parapsilosis<\/jats:named-content>\n and\n C. orthopsilosis<\/jats:named-content>\n increased to 4.8% and 0.3%, respectively; conversely, for\n C. parapsilosis<\/jats:named-content>\n they shifted from 1.9 to 0.6% (anidulafungin) and from 2.5 to 0.6% (micafungin). Our study confirms the different prevalence of\n C. parapsilosis<\/jats:named-content>\n complex candidemia among age groups: neither\n C. orthopsilosis<\/jats:named-content>\n nor\n C. metapsilosis<\/jats:named-content>\n was isolated from neonates; interestingly,\n C. metapsilosis<\/jats:named-content>\n was isolated only from adults and the elderly. The disparity in antifungal susceptibility among species could be important for therapy.\n <\/jats:p>","DOI":"10.1128\/aac.00466-11","type":"journal-article","created":{"date-parts":[[2011,9,20]],"date-time":"2011-09-20T04:18:33Z","timestamp":1316492313000},"page":"5590-5596","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":126,"title":["Prospective Multicenter Study of the Epidemiology, Molecular Identification, and Antifungal Susceptibility of Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis Isolated from Patients with Candidemia"],"prefix":"10.1128","volume":"55","author":[{"given":"Emilia","family":"Cant\u00f3n","sequence":"first","affiliation":[{"name":"Unidad de Microbiolog\u00eda Experimental, Hospital La Fe, Valencia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Pem\u00e1n","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital La Fe, Valencia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Quind\u00f3s","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Microbiolog\u00eda y Parasitolog\u00eda, Facultad de Medicina, Universidad del Pa\u00eds Vasco, Bilbao"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Eraso","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Microbiolog\u00eda y Parasitolog\u00eda, Facultad de Medicina, Universidad del Pa\u00eds Vasco, Bilbao"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilargi","family":"Miranda-Zapico","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Microbiolog\u00eda y Parasitolog\u00eda, Facultad de Medicina, Universidad del Pa\u00eds Vasco, 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Pedrosa","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital Ram\u00f3n y Cajal, Madrid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genoveva","family":"Yag\u00fce","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital Virgen de la Arrixaca, Murcia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remedios","family":"Guna","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital General, Valencia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Rubio","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital Cl\u00ednico Lozano Blesa, Zaragoza"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Consuelo","family":"Miranda","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital Virgen de la Nieves, 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