{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:21:06Z","timestamp":1791062466789,"version":"4.1.0"},"reference-count":39,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            A total of 5,282 bacterial isolates obtained between 1 January and 31 December 31 2008, inclusive, from patients in 10 hospitals across Canada as part of the Canadian Ward Surveillance Study (CANWARD 2008) underwent susceptibility testing. The 10 most common organisms, representing 78.8% of all clinical specimens, were as follows:\n            <jats:italic>Escherichia coli<\/jats:italic>\n            (21.4%), methicillin-susceptible\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            (MSSA; 13.9%),\n            <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n            (10.3%),\n            <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n            (7.1%),\n            <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n            (6.0%), coagulase-negative staphylococci\/\n            <jats:italic>Staphylococcus epidermidis<\/jats:italic>\n            (5.4%), methicillin-resistant\n            <jats:italic>S. aureus<\/jats:italic>\n            (MRSA; 5.1%),\n            <jats:italic>Haemophilus influenzae<\/jats:italic>\n            (4.1%),\n            <jats:italic>Enterococcus<\/jats:italic>\n            spp. (3.3%),\n            <jats:italic>Enterobacter cloacae<\/jats:italic>\n            (2.2%). MRSA comprised 27.0% (272\/1,007) of all\n            <jats:italic>S. aureus<\/jats:italic>\n            isolates (genotypically, 68.8% of MRSA were health care associated [HA-MRSA] and 27.6% were community associated [CA-MRSA]). Extended-spectrum \u03b2-lactamase (ESBL)-producing\n            <jats:italic>E. coli<\/jats:italic>\n            occurred in 4.9% of\n            <jats:italic>E. coli<\/jats:italic>\n            isolates. The CTX-M type was the predominant ESBL, with CTX-M-15 the most prevalent genotype. MRSA demonstrated no resistance to ceftobiprole, daptomycin, linezolid, telavancin, tigecycline, or vancomycin (0.4% intermediate intermediate resistance).\n            <jats:italic>E. coli<\/jats:italic>\n            demonstrated no resistance to ertapenem, meropenem, or tigecycline. Resistance rates with\n            <jats:italic>P. aeruginosa<\/jats:italic>\n            were as follows: colistin (polymyxin E), 0.8%; amikacin, 3.5%; cefepime, 7.2%; gentamicin, 12.3%; fluoroquinolones, 19.0 to 24.1%; meropenem, 5.6%; piperacillin-tazobactam, 8.0%. A multidrug-resistant (MDR) phenotype occurred frequently in\n            <jats:italic>P. aeruginosa<\/jats:italic>\n            (5.9%) but uncommonly in\n            <jats:italic>E. coli<\/jats:italic>\n            (1.2%) and\n            <jats:italic>K. pneumoniae<\/jats:italic>\n            (0.9%). In conclusion,\n            <jats:italic>E. coli<\/jats:italic>\n            ,\n            <jats:italic>S. aureus<\/jats:italic>\n            (MSSA and MRSA),\n            <jats:italic>P. aeruginosa<\/jats:italic>\n            ,\n            <jats:italic>S. pneumoniae<\/jats:italic>\n            ,\n            <jats:italic>K. pneumoniae<\/jats:italic>\n            ,\n            <jats:italic>H. influenzae<\/jats:italic>\n            , and\n            <jats:italic>Enterococcus<\/jats:italic>\n            spp. are the most common isolates recovered from clinical specimens in Canadian hospitals. The prevalence of MRSA was 27.0% (of which genotypically 27.6% were CA-MRSA), while ESBL-producing\n            <jats:italic>E. coli<\/jats:italic>\n            occurred in 4.9% of isolates. An MDR phenotype was common in\n            <jats:italic>P. aeruginosa.<\/jats:italic>\n          <\/jats:p>","DOI":"10.1128\/aac.00469-10","type":"journal-article","created":{"date-parts":[[2010,8,31]],"date-time":"2010-08-31T02:30:38Z","timestamp":1283221838000},"page":"4684-4693","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":127,"title":["Prevalence of Antimicrobial-Resistant Pathogens in Canadian Hospitals: Results of the Canadian Ward Surveillance Study (CANWARD 2008)"],"prefix":"10.1128","volume":"54","author":[{"given":"George G.","family":"Zhanel","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine"},{"name":"Departments of Medicine"},{"name":"Clinical Microbiology, Health Sciences Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"DeCorby","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine"},{"name":"Clinical Microbiology, Health Sciences Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine"},{"name":"Clinical Microbiology, Health Sciences Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Mulvey","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine"},{"name":"Nosocomial Infections Branch, National Microbiology Laboratory, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"McCracken","sequence":"additional","affiliation":[{"name":"Nosocomial Infections Branch, National Microbiology Laboratory, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lagace\u0301-Wiens","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine"},{"name":"Department of Clinical Microbiology, St. Boniface General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly A.","family":"Nichol","sequence":"additional","affiliation":[{"name":"Clinical Microbiology, Health Sciences Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Wierzbowski","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine"},{"name":"Clinical Microbiology, Health Sciences Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia J.","family":"Baudry","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine"},{"name":"Clinical Microbiology, Health Sciences Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franil","family":"Tailor","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine"},{"name":"Clinical Microbiology, Health Sciences Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Karlowsky","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine"},{"name":"Clinical Microbiology, Health Sciences Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Walkty","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine"},{"name":"Departments of Medicine"},{"name":"Clinical Microbiology, Health Sciences Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Schweizer","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine"},{"name":"Department of Chemistry, Faculty of Science, University of Manitoba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Johnson","sequence":"additional","affiliation":[{"name":"International Health Management Associates, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryl J.","family":"Hoban","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine"},{"name":"Clinical Microbiology, Health Sciences Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01316-09"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01176-07"},{"key":"e_1_3_2_4_2","first-page":"43","volume":"20","year":"2009","unstructured":"Baudry, P. J., M. McCracken, P. Lagac\u00e9-Wiens, M. Mulvey, G. G. Zhanel, and D. J. Hoban. 2009. Prevalence and characterization of extended-spectrum \u03b2-lactamase-producing Enterobacteriaceae isolated in Canadian hospitals: results from CANWARD 2007. Can. J. Infect. Dis. Med. Microbiol.20(Suppl. A):43-48.","journal-title":"Can. J. Infect. Dis. Med. Microbiol."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-009-8457-0"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2008.0827"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe058023"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/605562"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02500-06"},{"key":"e_1_3_2_10_2","unstructured":"Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; 8th edition M07-A8. 2009"},{"key":"e_1_3_2_11_2","unstructured":"Performance standards for antimicrobial susceptibility testing: 19th informational supplement document M100-S19. 2009"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/510393"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2006.12.022"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/321893"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.051565"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/754249"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2008.tb01820.x"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01076-09"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1086\/507636"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00576-07"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01284-07"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1202939"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.4.1204-1214.2004"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1106.041146"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/853676"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.7.2155-2161.2002"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01338-09"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01377-06"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00247-09"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2009.08.020"},{"key":"e_1_3_2_31_2","first-page":"69","volume":"7","year":"2007","unstructured":"Rubinstein, E., and G. G. Zhanel. 2007. Anti-infectives research and development problems challenges and solutions: the clinical practitioner perspective. Lancet Infect. Dis.7:69-70.","journal-title":"Lancet Infect. Dis."},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00582-08"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1086\/507960"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.33.9.2233-2239.1995"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp349"},{"key":"e_1_3_2_36_2","first-page":"1817","volume":"343","year":"2000","unstructured":"Whitney, C. G., M. M. Farley, and J. Hadler. 2000. Increasing prevalence of multi-drug resistant Streptococcus pneumoniae in the United States. N. Engl. J. Med.343:1817-1824.","journal-title":"N. Engl. J. Med."},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg352"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01538-07"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/714846"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/290130"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00469-10","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00469-10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:16:42Z","timestamp":1645474602000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00469-10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":39,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["10.1128\/AAC.00469-10"],"URL":"https:\/\/doi.org\/10.1128\/aac.00469-10","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11]]},"assertion":[{"value":"2010-04-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-08-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}