{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T15:31:40Z","timestamp":1781623900321,"version":"3.54.5"},"reference-count":51,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88881.188706\/2018-01"],"award-info":[{"award-number":["88881.188706\/2018-01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","award":["BB\/P504567\/1"],"award-info":[{"award-number":["BB\/P504567\/1"]}],"id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2020,7,22]]},"abstract":"<jats:p>\n            <jats:named-content content-type=\"genus-species\">Candida auris<\/jats:named-content>\n            has emerged as a multidrug-resistant nosocomial pathogen over the last decade. Outbreaks of the organism in health care facilities have resulted in life-threatening invasive candidiasis in over 40 countries worldwide. Resistance by\n            <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n            to conventional antifungal drugs such as fluconazole and amphotericin B means that alternative therapeutics must be explored. As such, this study served to investigate the efficacy of a naturally derived polysaccharide called chitosan against aggregative (Agg) and nonaggregative (non-Agg) isolates of\n            <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n            <jats:italic>in vitro<\/jats:italic>\n            and\n            <jats:italic>in vivo. In vitro<\/jats:italic>\n            results indicated that chitosan was effective against planktonic and sessile forms of Agg and non-Agg\n            <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.00476-20","type":"journal-article","created":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T14:06:11Z","timestamp":1591020371000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":33,"title":["Chitosan Ameliorates Candida auris Virulence in a Galleria mellonella Infection Model"],"prefix":"10.1128","volume":"64","author":[{"given":"La\u00eds Salom\u00e3o","family":"Arias","sequence":"first","affiliation":[{"name":"Oral Sciences Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom"},{"name":"S\u00e3o Paulo State University (Unesp), School of Dentistry, Department of Preventive and Restorative Dentistry, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark C.","family":"Butcher","sequence":"additional","affiliation":[{"name":"Oral Sciences Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom"},{"name":"Glasgow Biofilm Research Network, Glasgow Dental School, Glasgow, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryn","family":"Short","sequence":"additional","affiliation":[{"name":"Oral Sciences Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom"},{"name":"Glasgow Biofilm Research Network, Glasgow Dental School, Glasgow, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"McKloud","sequence":"additional","affiliation":[{"name":"Oral Sciences Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom"},{"name":"Glasgow Biofilm Research Network, Glasgow Dental School, Glasgow, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Delaney","sequence":"additional","affiliation":[{"name":"Oral Sciences Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom"},{"name":"Glasgow Biofilm Research Network, Glasgow Dental School, Glasgow, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Kean","sequence":"additional","affiliation":[{"name":"Department of Biological and Biomedical Sciences, School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, United Kingdom"},{"name":"Glasgow Biofilm Research Network, Glasgow Dental School, Glasgow, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas Roberto","family":"Monteiro","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (Unesp), School of Dentistry, Department of Preventive and Restorative Dentistry, S\u00e3o Paulo, Brazil"},{"name":"Graduate Program in Dentistry, University of Western S\u00e3o Paulo (UNOESTE), Prudente\/S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Williams","sequence":"additional","affiliation":[{"name":"Oral Sciences Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom"},{"name":"Glasgow Biofilm Research Network, Glasgow Dental School, Glasgow, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Ramage","sequence":"additional","affiliation":[{"name":"Oral Sciences Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom"},{"name":"Glasgow Biofilm Research Network, Glasgow Dental School, Glasgow, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8168-5333","authenticated-orcid":false,"given":"Jason L.","family":"Brown","sequence":"additional","affiliation":[{"name":"Oral Sciences Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom"},{"name":"Glasgow Biofilm Research Network, Glasgow Dental School, Glasgow, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof3040057"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/597108"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-019-00351-w"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw691"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00458-19"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof6010030"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01397-19"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2018.05.007"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2017.11.015"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2019.06.006"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2509.190686"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00189-16"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2302.161486"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2302.161320"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2010.09.012"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00602"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0210208"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2014.1839"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/527549"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2007.11.029"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00334-18"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02788"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2017.08.082"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/bm034130m"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12947"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41426-018-0187-x"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02319-17"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00083"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz280"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-2167-5"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.088930"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00543-15"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.12.5146-5148.2005"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00238-18"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14176"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01388-15"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1806005115"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00237-16"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myw147"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2018.11.023"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2020.111080"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioflm.2019.100010"},{"key":"e_1_3_3_44_2","volume-title":"Reference method for broth dilution antifungal susceptibility testing of yeasts","author":"Clinical and Laboratory Standards Institute","year":"2008","unstructured":"Clinical and Laboratory Standards Institute. 2008. Reference method for broth dilution antifungal susceptibility testing of yeasts; approved standard\u20143rd ed. CLSI document M27-A3. Clinical and Laboratory Standards Institute, Wayne, PA.","edition":"3"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.45.9.2475-2479.2001"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00067-15"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-14-182"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2016.12.006"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.4A6428.2004"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192562"},{"key":"e_1_3_3_52_2","unstructured":"Centers for Disease Control and Prevention. 2019. Candida auris : information for laboratorians and health professionals. Antifungal susceptibility testing and interpretation. Centers for Disease Control and Prevention Atlanta GA. https:\/\/www.cdc.gov\/fungal\/candida-auris\/c-auris-antifungal.html. Accessed May 2020."}],"updated-by":[{"DOI":"10.1128\/aac.02560-20","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000}}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00476-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00476-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:41:45Z","timestamp":1645479705000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00476-20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,22]]},"references-count":51,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,7,22]]}},"alternative-id":["10.1128\/AAC.00476-20"],"URL":"https:\/\/doi.org\/10.1128\/aac.00476-20","relation":{"correction":[{"id-type":"doi","id":"10.1128\/AAC.02560-20","asserted-by":"object"}]},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,22]]},"assertion":[{"value":"2020-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00476-20"}}